教授，博士生导师。2013年1月毕业于中国科学院化学研究所，获分析化学理学博士。一直从事生物体内活性物质的成像探针研究。已在Angew. Chem. Int. Ed.、J. Am. Chem. Soc.、Chem. Soc. Rev.、Redox Biology等国际学术期刊上发表学术论文40余篇。中国授权发明专利2项，美国授权发明专利2项。

主要研究方向:

1) 基于特异性化学反应的小分子光学探针与生物成像；

2) 光学性质可调控的新型近红外荧光染料与生物成像；

3) 生物体内与疾病相关的活性物质的调控与生物成像。

代表性论文:

1.     W. Chen, T. Matsunaga, D. L Neill, C. Yang, T. Akaike, M. Xian. Rational Design of a Dual-Reactivity Based Fluorescent Probe for Visualizing Intracellular HSNO. Angew. Chem. Int. Ed. 2019, 58, 16067-16070. ([Selected as a “Hot Paper” by the Editors][X-MOL News] [TAP-1 is the first fluorescent probe for HSNO])

2.     W. Chen, S. Xu, J. J. Day, D. Wang, M. Xian. A General Strategy for Development of Near-Infrared Fluorescent Probes for Bioimaging. Angew. Chem. Int. Ed. 2017, 56, 16611-16615. ([Science Newsline] [ScienceDaily News] [EurekAlert! Science News] [National Science Foundation News] [Medical News] [Technology Networks] [Phys.Org News] [Health Medicine Network News] [Lab Manager News] [Drug Target Review News])

3.     W. Chen, A. Pacheco, Y. Takano, J. J. Day, K. Hanaoka, M. Xian. A single fluorescent probe to visualize hydrogen sulfide and hydrogen polysulfides with different fluorescence signals. Angew. Chem. Int. Ed. 2016, 55, 9993-9996.([Highlighted as a Very Important Paper (VIP)] [ScienceDaily News] [Phys.org News] [Health Medicine Network News] [EurekAlert! Science News] [DDP-1 is the first fluorescent probe that can visualize H₂S and H₂S_n with different fluorescence signals])

4.     W. Chen, E. W. Rosser, T. Matsunaga, A. Pacheco, T. Akaike, M. Xian. The development of fluorescent probes for visualizing intracellular hydrogen polysulfides. Angew. Chem. Int. Ed. 2015, 54, 13961-13965. [PSP-3 is the most sensitive probe reported to date for H₂S_n]

5.     V. S. Lin†, W. Chen† (†Equal contribution), M. Xian, C. J. Chang. Chemical probes for molecular imaging and detection of hydrogen sulfide and reactive sulfur species in biological systems. Chem. Soc. Rev. 2015, 44, 4596-4618. [From themed collection Imaging Agents]

6.     C. Liu†, W. Chen† (†Equal contribution), W. Shi, B. Peng, Y. Zhao, H. Ma, M. Xian. Rational design and bioimaging applications of highly selective fluorescence probes for hydrogen polysulfides. J. Am. Chem. Soc. 2014, 136, 7257-7260.([DSP is the first fluorescent probe for H₂S_n (n>1)] [Probe DSP-3 is now commercially available from Chemodex Ltd])

授权专利与参编书稿

1．Ma H. M.; Chen W.; Shi W.; Li Z.; Liu Y.; Zhang J. H.; Liu Q. J. Patent No.: CN 102253019B

2．Ma H. M.; Chen W.; Li Z.; Shi W.; Liu Y.; Zhang J. H.; Liu Q. J. Patent No.: CN 102532177B

3. Xian M.; Chen W. Patent No.: US10520509B2

4. Xian M.; Chen W. Patent No.: US9494592B2

5. W. Chen, M. Xian. Chapter Seven - Washington Red (WR) dyes and their imaging applications. Methods in Enzymology 2020, 640, 149-163.

招生信息

招收具有化学、药学、化学生物学、生物医学工程、生物医学光子学及相关专业背景的博士生、硕士生、科研助理及博士后。

联系方式 w.chen@hust.edu.cn