Supervisor of Doctorate Candidates

Supervisor of Master's Candidates


Department:Wuhan National Laboratory for Optoelectronics

Education Level:Postgraduate (Doctoral)

Degree:Doctoral Degree in Science

Discipline:Analytical Chemistry
Organic Chemistry
Chemical Biology
Biomedical Engineering

Details >


Current position: Home >Profile:

教授,博士生导师。2013年1月毕业于中国科学院化学研究所,获分析化学理学博士。一直从事生物体内活性物质的成像探针研究。已在Angew. Chem. Int. Ed.、J. Am. Chem. Soc.、Chem. Soc. Rev.、Redox Biology等国际学术期刊上发表学术论文40余篇。中国授权发明专利2项,美国授权发明专利2项。


1) 基于特异性化学反应的小分子光学探针与生物成像;

2) 光学性质可调控的新型近红外荧光染料与生物成像;

3) 生物体内与疾病相关的活性物质的调控与生物成像。



1.     W. Chen, T. Matsunaga, D. L Neill, C. Yang, T. Akaike, M. Xian. Rational Design of a Dual-Reactivity Based Fluorescent Probe for Visualizing Intracellular HSNO. Angew. Chem. Int. Ed. 2019, 58, 16067-16070. ([Selected as a “Hot Paper” by the Editors][X-MOL News] [TAP-1 is the first fluorescent probe for HSNO])

2.     W. Chen, S. Xu, J. J. Day, D. Wang, M. Xian. A General Strategy for Development of Near-Infrared Fluorescent Probes for Bioimaging. Angew. Chem. Int. Ed. 2017, 56, 16611-16615. ([Science Newsline] [ScienceDaily News] [EurekAlert! Science News] [National Science Foundation News] [Medical News] [Technology Networks] [Phys.Org News] [Health Medicine Network News] [Lab Manager News] [Drug Target Review News])

3.     W. Chen, A. Pacheco, Y. Takano, J. J. Day, K. Hanaoka, M. Xian. A single fluorescent probe to visualize hydrogen sulfide and hydrogen polysulfides with different fluorescence signals. Angew. Chem. Int. Ed. 2016, 55, 9993-9996.([Highlighted as a Very Important Paper (VIP)] [ScienceDaily News] [ News] [Health Medicine Network News] [EurekAlert! Science News] [DDP-1 is the first fluorescent probe that can visualize H2S and H2Sn with different fluorescence signals])

4.     W. Chen, E. W. Rosser, T. Matsunaga, A. Pacheco, T. Akaike, M. Xian. The development of fluorescent probes for visualizing intracellular hydrogen polysulfides. Angew. Chem. Int. Ed. 2015, 54, 13961-13965. [PSP-3 is the most sensitive probe reported to date for H2Sn]

5.     V. S. Lin†, W. Chen† (†Equal contribution), M. Xian, C. J. Chang. Chemical probes for molecular imaging and detection of hydrogen sulfide and reactive sulfur species in biological systems. Chem. Soc. Rev. 2015, 44, 4596-4618. [From themed collection Imaging Agents]

6.     C. Liu†, W. Chen† (†Equal contribution), W. Shi, B. Peng, Y. Zhao, H. Ma, M. Xian. Rational design and bioimaging applications of highly selective fluorescence probes for hydrogen polysulfides. J. Am. Chem. Soc. 2014, 136, 7257-7260.([DSP is the first fluorescent probe for H2Sn (n>1)] [Probe DSP-3 is now commercially available from Chemodex Ltd])



1Ma H. M.; Chen W.; Shi W.; Li Z.; Liu Y.; Zhang J. H.; Liu Q. J. Patent No.: CN 102253019B

2Ma H. M.; Chen W.; Li Z.; Shi W.; Liu Y.; Zhang J. H.; Liu Q. J. Patent No.: CN 102532177B

3. Xian M.; Chen W. Patent No.: US10520509B2

4. Xian M.; Chen W. Patent No.: US9494592B2

5. W. Chen, M. Xian. Chapter Seven - Washington Red (WR) dyes and their imaging applications. Methods in Enzymology 2020, 640, 149-163.






Copyright © 2017 Huazhong University of Science & Technology

Click:times | The Founding Time:.. | The Last Update Time:.. | MOBILE Version