教授，博士生导师，国家高层次青年人才，中国光学学会生物医学光子学专业委员会委员，中国分析测试协会生物传感专业委员会委员，中国分析测试协会分子光谱专业委员会委员。2013年1月毕业于中国科学院化学研究所，获分析化学理学博士。一直从事生物体内活性物质的成像探针研究。已在Angew. Chem. Int. Ed.、J. Am. Chem. Soc.、Chem. Soc. Rev.、Anal. Chem.、Redox Biology等国际学术期刊上发表学术论文40余篇。中国授权发明专利2项，美国授权发明专利2项。

主要研究方向:

1) 基于特异性化学反应的小分子光学探针与生物成像；

2) 光学性质可调控的新型近红外荧光染料与生物成像；

3) 生物体内与疾病相关的活性物质的调控与生物成像。

Representative Publications:

     1.   X. Wei, L. He, D. He, X. Zhang, W. Chen*. Single-Atom C-to-N Editing Unlocks Bright NIR-II J-Aggregates for Imaging Lymphatic Metastasis. Angew. Chem. Int. Ed. 2026, e5207784. ([Selected as a “Hot Paper” by the Editors]

2.     J. Zhang, M. He, M. Huang, L. Liu, Y. He, D. He, F. Wang, W. Chen*. Carbonothioate-Triggered Cascade Cyclization Enables High-Specificity Fluorescence Imaging of Hydrogen Polysulfides. Angew. Chem. Int. Ed. 2025, 64, e202519021.[Featured as "Frontispiece"]

3.     W. Chen, T. Matsunaga, D. L Neill, C. Yang, T. Akaike, M. Xian*. Rational Design of a Dual-Reactivity Based Fluorescent Probe for Visualizing Intracellular HSNO. Angew. Chem. Int. Ed. 2019, 58, 16067-16070. ([Selected as a “Hot Paper” by the Editors][X-MOL News] [TAP-1 is the first fluorescent probe for HSNO])

4.     W. Chen, S. Xu, J. J. Day, D. Wang, M. Xian*. A General Strategy for Development of Near-Infrared Fluorescent Probes for Bioimaging. Angew. Chem. Int. Ed. 2017, 56, 16611-16615. ([Science Newsline] [ScienceDaily News] [EurekAlert! Science News] [National Science Foundation News] [Medical News] [Technology Networks] [Phys.Org News] [Health Medicine Network News] [Lab Manager News] [Drug Target Review News])

5.     W. Chen, A. Pacheco, Y. Takano, J. J. Day, K. Hanaoka, M. Xian*. A single fluorescent probe to visualize hydrogen sulfide and hydrogen polysulfides with different fluorescence signals. Angew. Chem. Int. Ed. 2016, 55, 9993-9996.([Highlighted as a Very Important Paper (VIP)] [ScienceDaily News] [Phys.org News] [Health Medicine Network News] [EurekAlert! Science News] [DDP-1 is the first fluorescent probe that can visualize H₂S and H₂S_n with different fluorescence signals])

6.     W. Chen, E. W. Rosser, T. Matsunaga, A. Pacheco, T. Akaike, M. Xian*. The development of fluorescent probes for visualizing intracellular hydrogen polysulfides. Angew. Chem. Int. Ed. 2015, 54, 13961-13965. [PSP-3 is the most sensitive probe reported to date for H₂S_n]

7.     C. Liu†, W. Chen† (†Equal contribution), W. Shi, B. Peng, Y. Zhao, H. Ma, M. Xian*. Rational design and bioimaging applications of highly selective fluorescence probes for hydrogen polysulfides. J. Am. Chem. Soc. 2014, 136, 7257-7260.([DSP is the first fluorescent probe for H₂S_n (n>1)] [Probe DSP-3 is now commercially available from Chemodex Ltd])

8.     W. Chen†, C. Liu† (†Equal contribution), B. Peng, Y. Zhao, A. Pacheco, M. Xian*. New fluorescent probes for sulfane sulfurs and the application in bioimaging. Chem. Sci. 2013, 4, 2892-2896.([Chemistry World News] [SSP is the first fluorescent probe for sulfane sulfurs][Probe SSP4 is now commercially available from Dojindo Molecular Technologies, Inc.])

Patents/ Books/ Reviews:

1．H. M. Ma; W. Chen; W. Shi; Z. Li; Y. Liu; J. H. Zhang; Q. J. Liu. Patent No.: CN 102253019B

2．H. M. Ma; W. Chen; Z. Li; W. Shi; Y. Liu; J. H. Zhang; Q. J. Liu. Patent No.: CN 102532177B

3. M. Xian; W. Chen Patent No.: US10520509B2

4. M. Xian; W. Chen Patent No.: US9494592B2

5. W. Chen, M. Xian. Chapter Seven - Washington Red (WR) dyes and their imaging applications. Methods in Enzymology 2020, 640, 149-163.

6. V. S. Lin†, W. Chen† (†Equal contribution), M. Xian*, C. J. Chang*. Chemical probes for molecular imaging and detection of hydrogen sulfide and reactive sulfur species in biological systems. Chem. Soc. Rev. 2015, 44, 4596-4618. [From themed collection Imaging Agents]

7. J. Zhang, X. Wei, Y. Deng, X. Wu*, W. Chen*. Small-molecule fluorescent probes for sulfur redox biology in oxidative stress. Coord. Chem. Rev. 2026, 554, 217597.

8. X. Wei, W. Chen*. Fluorescent J-Aggregates in the NIR-II Window: Unlocking Frontiers in Biomedical Imaging. Chem. Biomed. Imaging 2026, 4, 957–969.[From special issue “New Chemistry and Emerging Technologies for Molecular Imaging”]

招生信息：

招收具有化学、药学、生物学、生物医学工程及相关专业背景的研究生及博士后。

联系方式 w.chen@hust.edu.cn