Indexed by: Journal paper

Document Code: JNCI J Natl Cancer Inst

First Author: xie lin

Correspondence Author: Jiang Fc

Co-author: Lin Xie, Feng-Chao Jiang, Li-Min Zhang, Wen-Tao He, Jian-Hua Liu

Included Journals: SCI

Discipline: Medicine

First-Level Discipline: Basic Medicine

Document Type: J

Volume: 108

Issue: 4

Key Words: MyD88，Colorectal Cancer

Date of Publication: 2016-01-03

Abstract: Background: The TLR/MyD88 signaling pathway is an important driver of inflammation and cancer and is a possible target for antitumor therapy. Methods: We generated a MyD88 inhibitor (TJ-M2010-5), which was designed to bind to the TIR domain of MyD88 to interfere with its homodimerization, and the TLR/MyD88 signal pathway. We utilized a mouse model of azoxymethane/ dextran sodium sulfate (AOM/DSS)–induced colitis-associated cancer (CAC) in combination with TJ-M2010-5 administration to investigate the anti-inflammation–related cancer effect of MyD88 inhibitor in vivo. Data were analyzed with one