At the basic research level, we will reveal the molecular mechanisms of neurotransmitter and neuromodulin secretion, the basic principles of synapse formation and maintenance of synaptic homeostasis, the mechanisms of immune synapse formation and secretion of killer particles, and the regulation of tumor exosome secretion; at the translational level, we will realize the potential diagnosis and treatment of neurodegenerative diseases, autoimmune diseases, and tumor diseases.