Boosting the Photodynamic Degradation of Islet Amyloid Polypeptide Aggregates via a “Bait-Hook-Devastate” Strategy
发布时间：2023-07-20
点击次数：
- 发表刊物：
- ACS Applied Materials & Interfaces
- 收录刊物：
- SCI
- 卷号：
- 13
- 期号：
- 13
- 页面范围：
- 14911–14919
- ISSN号：
- 1944-8244
- 关键字：
- amyloidogenic diseases amyloid aggregates photodynamic degradation polymer electrostatic interaction
- DOI码：
- 10.1021/acsami.1c00082
- 发表时间：
- 2021-03-25
- 影响因子：
- 9.229
- 摘要：
- Photosensitizers that can generate reactive oxygen species (ROS) upon irradiation have emerged as promising agents for photodynamic degradation of toxic amyloid aggregates that are linked to many amyloidogenic diseases. However, due to the ultrastable β-sheet structure in amyloid aggregates and inefficient utilization of the generated ROS, it usually requires high stoichiometric concentration of the photosensitizer and/or intensive light irradiation to fully dissociate aggregates. In this work, we have developed a “bait-hook-devastate” strategy to boost the efficiency of the photodynamic degradation of amyloid aggregates. This strategy employs anionic polyacrylic acid as a bait to accumulate cationic human islet amyloid polypeptide (IAPP) aggregates and positively charged photosensitizer TPCI in a confined area through electronic interactions. Multiple characterization studies proved that the utilization rate of ROS generated by TPCI was remarkably improved via this strategy, which amplified the ability of TPCI to dissociate IAPP aggregates. Rapid and complete degradation of IAPP aggregates could be achieved by irradiating the system under very mild conditions for less than 30 min, and the IAPP-mediated cytotoxicity was also largely alleviated, providing a new paradigm to accelerate photodynamic degradation of amyloid aggregates for further practical applications.