Sheng Wang

Association Professor, College of Life Science and Technology

Research Interestings:

Biomacromolecular functions based their structures by xtal technologies and related methods; Drugdesign target biomarcromolecules for specific diseases of Human.

Mechanisms of Biomacromelecules by Computational Structural Biology.

Published Articles

1. Lei Luo^#, Bowen Li^#, Sheng Wang^#, Fangming Wu^#, Xiaochen Wang, Ping Liang, Rose Ombati, Junji Chen, Xiancui Lu, Ming Zhou^*, Jianmin Cui, Qiumin Lu, Longhua Zhang, Changlin Tian^*, Shilong Yang^* and Ren Lai^*，Centipedes subdue giant prey by blocking KCNQ channels，Proceedings of the National Academy of Sciences of the United States of America，2018，115(7): 1646–1651.

2. Guan XingLei^#, Wu PengFei^#, Wang Sheng^#, Zhang JuanJuan, Shen ZuCheng, Luo Han, Chen Hao, Long LiHong, Chen JianGuo^*, Wang Fang^*, Dimethyl sulfide protects against oxidative stress and extends lifespan via a methionine sulfoxide reductase A-dependent catalytic mechanism, Aging Cell, 2016, 16 (2): 226-236

3. Feng Han^#, Sheng Wang^#, Ling Guo, Aviansh S. Punekar, Rudolf  Ladenstein, Da-Cheng Wang^* and Wei Liu^*, MD simulation of crystal structures reveals post-translational modification dependent conformational changes in heat shock factor - DNA interaction, Protein & Cell, 2016, 7(12): 916–920

4. Ying Wu^#, Yu Xiong^#, Sheng Wang^#, Hong Yi, Hui Li, Na Pan, Frank T. Horrigan, Yingliang Wu^* & Jiuping Ding^*, Intersubunit Coupling in the Pore of BK Channels，J. Biol. Chem., 2009，284: 23353-23363

5. Xiying Guo, Haowen Liu, Zhigang Huang, Yanting Wang, Yan Zhang, Lu-Yang Wang, Chunyang Cao, Sheng Wang and Jiuping Ding, Rectification ratio based determination of disulfide bonds of b2 extracellular loop of BK channel, Channels, 2019, 13(1):17-32

6.Zhi-Gang Huang^#, Hao-Wen Liu^#, Zhen-Zhen Yan, Sheng Wang*, Lu-Yang Wang* & Jiu-Ping Ding*, The glycosylation of the extracellular loop of b2 subunits diversifies functional phenotypes of BK Channels, Channels, 2017, 11(2): 156-166

7. Chun Zhang^#*, Zhen Wang, Liangxiao Tan, Tian-Long Zhai, Sheng Wang*, Bien Tan*, Yan-Song Zheng*, Xiang-Liang Yang, and Hui-Bi Xu, A Porous Tricycloo -xacalixarene Cage Based on Tetraphenylethylene，Angew. Chem. Int. Ed., 2015, 54: 9244 -9248

8. Tianfu Cai, Ji Luo, Er Meng, Jiuping Ding, Songping Liang, Sheng Wang*, Zhonghua Liu*，Mapping the interaction site for the tarantula toxin hainantoxin-IV (b-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels, Peptides, 68, 2015: 148-156

9. Panpan Hou^#, Wenping Zeng^#, Geliang Gan^#, Caixia Lv^#, Xiying Guo, Zheng Zhang, Haowen Liu, Ying Wu, Jing Yao, Aguan D. Wei, Sheng Wang* & Jiuping Ding*，Inter-a/b subunits coupling mediating pre-inactivation and augmented activation of BKCa(b2), Scientific Reports, 2013, 3: 1666

10.王彦婷，黄智刚，郭西英，汪盛*，多二硫键蛋白在大肠杆菌中的表达研究，生命科学研究，2015，19(3): 258-264

11. 王彦婷，郭西英，黄智刚，汪盛*, 大电导钾离子通道(BK)结构与功能的研究进展，生物化学与生物物理进展, 2015, 42(4): 313-322

12. Pan Li^#, Haowen Liu^#, Chaohua Lai, Peibei Sun, Wenping Zeng, Fangming Wu, Longhua Zhang, Sheng Wang*, Changlin Tian* & Jiuping Ding*，Differential Modulations of KCNQ1 by Auxiliary Proteins KCNE1 and KCNE2, Scientific Reports, 2014, 4: 4973

13. HaoWen Liu^#, PanPan Hou^#, XiYing Guo^#, ZhiWen Zhao, Bin Hu, Xia Li, LuYang Wang, JiuPing Ding* & Sheng Wang*, Structural Basis for Calcium and Magnesium Regulation of a Large Conductance Calcium-activated Potassium Channel with b1 Subunits, J. Biol. Chem., 2014, 289: 16914-16923

14. Han Feng, Xuehui Liu, Sheng Wang, Joy Fleming, Da-Cheng Wang & Wei Liu, The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis, Nature Communications, 2017, 8: 2242

15. Li Yuan-Long, Wu Peng-Fei, Chen Jian-Guo, Wang Sheng, Han Qian-Qian, Li Dan, Wang, Wen, Guan Xin-Lei, Li Di, Long Li-Hong, Huang Jian-Geng, Wang Fang*, Activity-Dependent Sulfhydration Signal Controls N-Methyl-D-Aspartate Subtyp e Glutamate Receptor-Dependent Synaptic Plasticity via Increasing D-Serine Availability, ANTIOXIDANTS & REDOX SIGNALING, 2017, 27(7): 398-414

16. Shanshan Liu, Xiaoyang Jiao, Sheng Wang, Wenzhe Su, Lingzhi Jiang, Xin Zhang Changwen Ke* & Ping Xiong*, Susceptibility of influenza A(H1N1)/pdm2009, seasonal A(H3N2) and B viruses to Oseltamivir in Guangdong, China between 2009 and 2014, Scientific Reports, 2017, 7: 8488

17. Fei Wang^#, Zhenzhen Yan^#, Zhuguo Liu^#, Sheng Wang, Qiaoling Wu, Shuo Yu, Jiuping Ding*, Qiuyun Dai*, Molecular basis of toxicity of N-type calcium channel inhibitor MVIIA, Neuropharmacology, 2016, 101: 137-145

18. Wang Shuo^#, Du Tianpeng^#, Liu Zhuguo, Wang Sheng, Wu Ying, Ding Jiuping, Jiang Ling*, Dai Qiuyun*, Characterization of a T-super family conotoxin TxVC from Conus textile that selectively targets neuronal nAChR subtypes, Biochemical and Biophysical Research Communications, 2014, 454(1): 151-156

19. Rui Liu^#, Zheng Zhang^#, Huan Liu^#, Panpan Hou, Jun Lang, Sheng Wang, Hongli Yan, Pengcheng Li, Zhigang Huang, Hongbing Wu, Mingqiang Rong, Jian Huang, Hong Wang, Longbao Lv, Mingfeng Qiu, Jiuping Ding*, Ren Lai*, Human b-Defensin 2 Is a Novel Opener of Ca²⁺-Activated Potassium Channels and Induces Vasodilation and Hypotension in Monkeys, Hypertension, 2013, 62:415-425