汪盛
个人信息
Personal information
副教授 硕士生导师
性别:男
在职信息:在职
所在单位:生命科学与技术学院
学历:研究生(博士)毕业
学位:工学博士学位
毕业院校:重庆大学
学科:生理学微生物学
神经生物学
生物化学与分子生物学
生物物理学
生物学其他专业
个人简介
汪盛,华中科技大学生命科学与技术学院副教授,从事疾病相关的结构与计算生物学研究,并利用相关技术X射线单晶衍射,X射线小角散射,核磁共振,以及计算机虚拟药物设计与筛选等,开展基于结构和机制的合理分子设计、结构优化以及机制研究,理性开发潜在应用新颖功能性分子。 有着多年主讲经构生物学,药物分子设计等本科课程的教学经历。同时,结合实验室专业性强的特点,结合实际项目和优势平台,提高并强化训练专业技术,旨在培养强应用型人才。在国际著名杂志Angew. Chem. Int. Ed., PNAS, Aging Cell, Hypertension, Peptides, Protein and Cell, Neuropharmacology, JBC, Scientific Report,Channels等杂志上发表一系列研究性论文。 先后参与了973、863、国家重点研发计划等重大科研项目,主持过教育部、湖北省、广东省等省部级项目。
已发表的论文
1. Lei Luo#, Bowen Li#, Sheng Wang#, Fangming Wu#, Xiaochen Wang, Ping Liang, Rose Ombati, Junji Chen, Xiancui Lu, Ming Zhou*, Jianmin Cui, Qiumin Lu, Longhua Zhang, Changlin Tian*, Shilong Yang* and Ren Lai*,Centipedes subdue giant prey by blocking KCNQ channels,Proceedings of the National Academy of Sciences of the United States of America,2018,115(7): 1646–1651.
2. Guan XingLei#, Wu PengFei#, Wang Sheng#, Zhang JuanJuan, Shen ZuCheng, Luo Han, Chen Hao, Long LiHong, Chen JianGuo*, Wang Fang*, Dimethyl sulfide protects against oxidative stress and extends lifespan via a methionine sulfoxide reductase A-dependent catalytic mechanism, Aging Cell, 2016, 16 (2): 226-236
3. Feng Han#, Sheng Wang#, Ling Guo, Aviansh S. Punekar, Rudolf Ladenstein, Da-Cheng Wang* and Wei Liu*, MD simulation of crystal structures reveals post-translational modification dependent conformational changes in heat shock factor - DNA interaction, Protein & Cell, 2016, 7(12): 916–920
4. Ying Wu#, Yu Xiong#, Sheng Wang#, Hong Yi, Hui Li, Na Pan, Frank T. Horrigan, Yingliang Wu* & Jiuping Ding*, Intersubunit Coupling in the Pore of BK Channels,J. Biol. Chem., 2009,284: 23353-23363
5. Xiying Guo, Haowen Liu, Zhigang Huang, Yanting Wang, Yan Zhang, Lu-Yang Wang, Chunyang Cao, Sheng Wang and Jiuping Ding, Rectification ratio based determination of disulfide bonds of b2 extracellular loop of BK channel, Channels, 2019, 13(1):17-32
6.Zhi-Gang Huang#, Hao-Wen Liu#, Zhen-Zhen Yan, Sheng Wang*, Lu-Yang Wang* & Jiu-Ping Ding*, The glycosylation of the extracellular loop of b2 subunits diversifies functional phenotypes of BK Channels, Channels, 2017, 11(2): 156-166
7. Chun Zhang#*, Zhen Wang, Liangxiao Tan, Tian-Long Zhai, Sheng Wang*, Bien Tan*, Yan-Song Zheng*, Xiang-Liang Yang, and Hui-Bi Xu, A Porous Tricycloo -xacalixarene Cage Based on Tetraphenylethylene,Angew. Chem. Int. Ed., 2015, 54: 9244 -9248
8. Tianfu Cai, Ji Luo, Er Meng, Jiuping Ding, Songping Liang, Sheng Wang*, Zhonghua Liu*,Mapping the interaction site for the tarantula toxin hainantoxin-IV (b-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels, Peptides, 68, 2015: 148-156
9. Panpan Hou#, Wenping Zeng#, Geliang Gan#, Caixia Lv#, Xiying Guo, Zheng Zhang, Haowen Liu, Ying Wu, Jing Yao, Aguan D. Wei, Sheng Wang* & Jiuping Ding*,Inter-a/b subunits coupling mediating pre-inactivation and augmented activation of BKCa(b2), Scientific Reports, 2013, 3: 1666
10.王彦婷,黄智刚,郭西英,汪盛*,多二硫键蛋白在大肠杆菌中的表达研究,生命科学研究,2015,19(3): 258-264
11. 王彦婷,郭西英,黄智刚,汪盛*, 大电导钾离子通道(BK)结构与功能的研究进展,生物化学与生物物理进展, 2015, 42(4): 313-322
12. Pan Li#, Haowen Liu#, Chaohua Lai, Peibei Sun, Wenping Zeng, Fangming Wu, Longhua Zhang, Sheng Wang*, Changlin Tian* & Jiuping Ding*,Differential Modulations of KCNQ1 by Auxiliary Proteins KCNE1 and KCNE2, Scientific Reports, 2014, 4: 4973
13. HaoWen Liu#, PanPan Hou#, XiYing Guo#, ZhiWen Zhao, Bin Hu, Xia Li, LuYang Wang, JiuPing Ding* & Sheng Wang*, Structural Basis for Calcium and Magnesium Regulation of a Large Conductance Calcium-activated Potassium Channel with b1 Subunits, J. Biol. Chem., 2014, 289: 16914-16923
14. Han Feng, Xuehui Liu, Sheng Wang, Joy Fleming, Da-Cheng Wang & Wei Liu, The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis, Nature Communications, 2017, 8: 2242
15. Li Yuan-Long, Wu Peng-Fei, Chen Jian-Guo, Wang Sheng, Han Qian-Qian, Li Dan, Wang, Wen, Guan Xin-Lei, Li Di, Long Li-Hong, Huang Jian-Geng, Wang Fang*, Activity-Dependent Sulfhydration Signal Controls N-Methyl-D-Aspartate Subtyp e Glutamate Receptor-Dependent Synaptic Plasticity via Increasing D-Serine Availability, ANTIOXIDANTS & REDOX SIGNALING, 2017, 27(7): 398-414
16. Shanshan Liu, Xiaoyang Jiao, Sheng Wang, Wenzhe Su, Lingzhi Jiang, Xin Zhang Changwen Ke* & Ping Xiong*, Susceptibility of influenza A(H1N1)/pdm2009, seasonal A(H3N2) and B viruses to Oseltamivir in Guangdong, China between 2009 and 2014, Scientific Reports, 2017, 7: 8488
17. Fei Wang#, Zhenzhen Yan#, Zhuguo Liu#, Sheng Wang, Qiaoling Wu, Shuo Yu, Jiuping Ding*, Qiuyun Dai*, Molecular basis of toxicity of N-type calcium channel inhibitor MVIIA, Neuropharmacology, 2016, 101: 137-145
18. Wang Shuo#, Du Tianpeng#, Liu Zhuguo, Wang Sheng, Wu Ying, Ding Jiuping, Jiang Ling*, Dai Qiuyun*, Characterization of a T-super family conotoxin TxVC from Conus textile that selectively targets neuronal nAChR subtypes, Biochemical and Biophysical Research Communications, 2014, 454(1): 151-156
19. Rui Liu#, Zheng Zhang#, Huan Liu#, Panpan Hou, Jun Lang, Sheng Wang, Hongli Yan, Pengcheng Li, Zhigang Huang, Hongbing Wu, Mingqiang Rong, Jian Huang, Hong Wang, Longbao Lv, Mingfeng Qiu, Jiuping Ding*, Ren Lai*, Human b-Defensin 2 Is a Novel Opener of Ca2+-Activated Potassium Channels and Induces Vasodilation and Hypotension in Monkeys, Hypertension, 2013, 62:415-425