论文类型：期刊论文
第一作者：王会敏,蔡晶涛
通讯作者：王涛
发表刊物：Biosensors and Bioelectronics
收录刊物：SCI
所属单位：华中科技大学
刊物所在地：美国
学科门类：工学
一级学科：生物医学工程
项目来源：国基金
文献类型：J
卷号：295
页面范围：116295-1-116295-7
关键字：Hyperbolic metamaterial Functionalized gold nanoparticle Plasmonic biosensor Carcinoembryonic antigen
发表时间：2024-04-12
影响因子：12.0
教研室：武汉光电国家研究中心
摘要：Hyperbolic metamaterial (HMM) biosensors based on metals have superior performance in comparison with conventional plasmonic biosensors in the detection of low concentrations of molecules. In this study, a nanorod HMM (NHMM) biosensor based on refractive index changes for carcinoembryonic antigen (CEA) detection is developed using secondary antibody modified gold nanoparticle (AuNP-Ab2) nanocomposites as signal amplification element for the first time. Numerical analysis based on finite element method is conducted to simulate the perturbation of the electric field of bulk plasmon polariton (BPP) supported by a NHMM in the presence of a AuNP. The simulation reveals an enhancement of the localized electric field, which arises from the resonant coupling of BPP to the localized surface plasmon resonance supported by AuNPs and is beneficial for the detection of changes of the refractive index. Furthermore, the AuNP-Ab2 nanocomposites-based NHMM (AuNP/Ab2-NHMM) biosensor enables CEA detection in the visible and near-infrared regions simultaneously. The highly sensitive detection of CEA with a wide linear range of 1–500 ng/mL is achieved in the near-infrared region. The detectable concentration of the AuNP/Ab2-NHMM biosensor has a 50-fold decrease in comparison with a NHMM biosensor. A low detection limit of 0.25 ng/mL (1.25 pM) is estimated when considering a noise level of 0.05 nm as the minimum detectable wavelength shift. The proposed method achieves high sensitivity and good reproducibility for CEA detection, which makes it a novel and viable approach for biomedical research and early clinical diagnostics.
发布期刊链接：https://www.sciencedirect.com/science/article/pii/S0956566324003002?via%3Dihub