论文类型：期刊论文
发表刊物：Additive Manufacturing
收录刊物：SCI
卷号：47
期号：3
发表时间：2021-08-01
摘要：The simultaneous achievement of admirable mechanical compatibility and osteoinduction in metallic implants can avoid stress shielding and facilitate osseointegration and osteogenesis. Herein, we reported a titanium-tantalum (Ti-Ta) Gyroid scaffold in-situ fabricated with selective laser melting (SLM), a powder-bed-fusion three-dimensional (3D) printing process, enabling superb elastic admissible strain (EAS), bioactivity and in-situ bone regeneration capability. The printed scaffold with 90% porosity exhibited a good combination of low elastic modulus (1.8 GPa) and high compressive yield strength (55.5 MPa), resulting in a superb EAS (3.03%) that is suitable for the reconstruction of cancellous bone. The mechanisms of the high EAS were ascribed to the formation of β(Ti, Ta) solid solution, ultrafine β grains accompanying with nanocrystalline α' grains, and the existence of dislocations and stacking faults. Bone-like apatite was spontaneously induced on the surface of the printed Ti-Ta alloy due to the generation of a self-passivating Ta2O5 film, indicating a good biomineralization ability. Compared to pure Ti, the printed Ti-Ta alloy exhibited an enhanced expression of vinculin, earlier cell extension, increased nuclei density, better cell proliferation, and the up-regulated expression of osteogenesis genes. Animal studies further validated that the printed Ti-Ta scaffold was capable to reinforce bone integration and accelerate bone regeneration. These findings provided a promising strategy for treating bone defects through 3D printing of metallic scaffolds.