钟芳锐

基本信息Personal Information

教授 博士生导师 硕士生导师

性别 : 男

毕业院校 : 新加坡国立大学

学历 : 研究生(博士)毕业

学位 : 理学博士学位

在职信息 : 在职

所在单位 : 化学与化工学院

学科 : 有机化学

曾获荣誉:

2017    Thieme Chemistry Journal Award

2017    湖北省百人计划入选者

2017    华中科技大学优秀教师班主任

2012    国家优秀自费留学生奖学金

2012    Reaxys Phd Prize finalist

2013    新加坡国立大学 Wang Gungwu Medal & Prize

2013    Singapore National Institute of Chemistry Gold Medal

2013    德国洪堡学者

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个人简介Personal Profile

 

课题组最新动态请参阅课题组主页:http://orgsyn.chem.hust.edu.cn/index.htm

 

导师介绍

钟芳锐,华中科技大学化学与化工学院教授,博士生导师,湖北省百人计划入选者。2008年本科毕业于浙江大学化学系,2012年获得新加坡国立大学博士学位,师从知名有机化学家卢一新教授,2013年至2015年先后在德国慕尼黑工业大学和乌尔姆大学从事博士后研究,德国洪堡学者(合作导师为德国科学院院士Thorsten Bach教授),2015年12月起任华中科技大学教授,2017年入选湖北省百人计划。

钟芳锐教授主要从事绿色有机合成化学领域的研究,主要方向包括绿色仿生催化、不对称催化合成和生物兼容性反应的开发等。研究成果已在国际权威期刊发表论文40余篇,第一及通讯作者在包括J. Am. Chem. Soc.,Angew. Chem. Int. Ed., ACS Catal.等期刊发表论文20余篇,中国发明专利公开6项。主持和参与科技部“合成生物学”重点研究计划、国家自然科学基金、湖北省科技厅技术创新重大专项、深圳市基础研究项目等项目,获得新加坡化学会金质奖章、Thieme Chemistry Journal Award、德国洪堡奖学金、国家优秀留学生奖等荣誉。

 

研究方向

不对称催化合成

生物兼容性反应开发与应用

绿色合成化学

 

代表性论文

10. Qile Yu, Yu Fu, Jianjian Huang, Jingyang Qin, Honghua Zuo, Yuzhou Wu*, Fangrui Zhong*, "Enantioselective Oxidative Phenol-Indole [3+ 2] Coupling Enabled by Biomimetic Mn (III)/Brønsted Acid Relay Catalysis" ACS Catal. 2019, 9, 7285.

9. Chun Ding, Xuan Zhang, Liang Shen, Jiaqi Huang, Ang Lu, Fangrui Zhong*, Yan Wang*, "Application of polysaccharide derivatives as novel draw solutes in forward osmosis for desalination and protein concentration", Chemical Engineering Research and Design, 2019,146, 211.

8. Yufeng Shi, Yufan Wang, Xunbo Lu, Yulong Zhang, Yuzhou Wu, Fangrui Zhong*, "Rhodium-catalyzed aminohydroxylation of unactivated alkenes in aqueous media for the benign synthesis of 1, 2-amino alcohols" Green Chem, 2019, 21, 780.

7. Yan Li, Longjie Li, Xunbo Lu, Yulong Bai, Yufan Wang, Yuzhou Wu* and Fangrui Zhong* "Bioinspired radical cyclization of tryptamines: synthesis of peroxypyrroloindolenines as potential anti-cancer agents" Chem. Commun., 2019, 55, 63.

6. Xunbo Lu, Yulong Bai, Yan Li, Yufeng Shi, Longjie Li, Yuzhou Wu and Fangrui Zhong* "Assembly of C3a-Peroxylated Pyrroloindolines via Interrupted Witkop Oxidation" Org. Lett., 2018, 20, 7937.

5. Yang Ni, Honghua Zuo, Huaibin Yu, Yuzhou Wu, and Fangrui Zhong* "Synergistic Catalysis-Enabled Thia-Aza-Prins Cyclization with DMSO and Disulfides: Entry to Sulfenylated 1,3-Oxazinanes and Oxazolidines" Org. Lett. 2018, 20, 5899.

4. Yang Ni, Honghua Zuo, Yan Li, Yuzhou Wu, and Fangrui Zhong*  "Copper-Catalyzed Regioselective Intramolecular Electrophilic Sulfenoamination via Lewis Acid Activation of Disulfides under Aerobic Conditions"  Org. Lett. 2018, 20, 4350.

3.Yushuang Yu, Yu Fu, Fangrui Zhong*, "Benign catalysis with iron: facile assembly of cyclobutanes and cyclohexenes via intermolecular radical cation cycloadditions" Green Chem. 2018, 21, 1743.

2. Yang Ni, Qile Yu, Qihao Liu, Honghua Zuo, Huai-Bin Yu, Wen-Jie Wei, Rong-Zhen Liao, and Fangrui Zhong*, "Iron-Catalyzed Regiospecific Intermolecular Radical Cyclization of Anilines: Strategy for Assembly of 2,2-Disubstituted Indolines" Org. Lett., 2018, 20, 1404.

1. Xunbo Lu,Yufeng Shi and Fangrui Zhong* "Rhodium-catalyzed intermolecular C(sp3)–Hamination in a purely aqueous system" Green Chem. 2018, 20, 113.(This article is part of the themed collection: 2018 Green Chemistry Hot Articles)

 

Prior to HUST

 1. Tianli Wang, Xiaoyu Han, Fangrui Zhong, Weijun Yao, Yixin Lu. “Amino acid-derived Bifunctional Phosphines for Enantioselective Transformations”Acc. Chem. Res.,2016, 49, 1369.

2. Fangrui Zhong, Alexander Pöthig, Thorsten Bach. “Synergistic Stereocontrol in the Enantioselective Ruthenium- catalyzed Sulfoxidation of Spirodithiolane-Indolones”Chem. Eur. J. 2015, 21, 10310.

3. Tianli Wang, Weijun Yao, Fangrui Zhong, Guohao Pang, Yixin Lu. “Phosphine-Catalyzed Enantioselective g-Addition of 3-Substituted Oxindoles to 2,3-Butadienoates and 2-Butynoates: Use of Prochiral Nucleophiles”,Angew. Chem. Int. Ed. 2014, 53, 2964.

4. Fangrui Zhong, Thorsten Bach. “Enantioselective Construction of 2,3-Dihydrofuro[2,3-b]quinolines through Supramolecular Hydrogen Bonding Interactions”Chem. Eur. J. 2014, 20, 13522.

5. Fangrui Zhong,Xiaowei Dou, Weijun Yao, Qiang Zhu, Yixin Lu.“Chiral Phosphine-Catalyzed Asymmetric Michael Addition of Oxindoles”Angew. Chem. Int.Ed. 2013, 52, 943.(highlighted in SYNFACTS2013, 216)

6. Jie Luo, Haifei Wang, Fangrui Zhong, Jacek, Kwiatkowski, Li-Wen Xu, Yixin Lu. “Highly diastereoselective and enantioselective direct Michael addition of phthalide derivatives to nitroolefins”Chem. Commun. 2013, 49, 5775.

7. Xiaowei Dou, Bo Zhou, Weijun Yao, Fangrui Zhong, Chunhui Jiang, Yixin Lu. “A Facile and Versatile Approach for the Asymmetric Synthesis of Oxindoles with a 3-Sulfenyl -substituted Quaternary Stereocenter”.Org. Lett. 2013, 15, 4920.

8. Fangrui Zhong,Jie Luo, Guo-Ying Chen, Xiaowei Dou, Yixin Lu. “Highly Enantioselective Regiodivergent Allylic Alkylations of MBH Adducts with Phthalides”J. Am. Chem. Soc. 2012, 134, 10222.(highlighted in SYNFACTS 2012, 906)

9. Fangrui Zhong, Xiaoyu Han, Youqing Wang, Yixin Lu. “Highly Enantioselective [4 + 2] Annulations Catalyzed by Amino Acid-Based Phosphines: Synthesis of Functionalized Cyclohexenes and 3-Spirocyclohexene-2-oxindoles”,Chem. Sci. 2012, 3, 1231.

10. Xiaoyu Han, Fangrui Zhong, Youqing Wang, Yixin Lu. “Versatile Enantioselective [3 + 2] Cyclization between Imines and Allenoates Catalyzed by Dipeptide-Based Phosphines”,Angew. Chem. Int. Ed. 2012, 51, 767.

11. Jie Luo, Haifei Wang, Fangrui Zhong, Jacek Kwiatkowski, Li-Wen Xu, Yixin Lu. “Direct Asymmetric Mannich Reaction of Phthalides: Facile Access to Chiral Substituted Isoquinolines and Isoquinolinones”,Chem. Commun. 2012, 48, 4707.

12. Xiaowei Dou,Fangrui Zhong,Yixin Lu. “A Highly Enantioslective Synthesis of Functionalized 2,3-Dihydrofurans via a Modified Feist−Bénary Reaction”Chem. Eur.J. 2012, 18, 13945.

13. Guo-Ying Chen, Fangrui Zhong, Yixin Lu. “Asymmetric Allylic Alkylation of Isatin-derived Morita-Baylis-Hillman Carbonates with Nitroalkanes”,Org. Lett. 2012, 14, 3955.

14. Fangrui Zhong,Weijun Yao, Xiaowei Dou, Yixin Lu. “Enantioselective Construction of 3-Hydroxy Oxindoles via Decarboxylative Addition of b-Ketoacids to Isatins”Org. Lett.2012, 14, 4018.

15. Fangrui Zhong,Guoying Chen, Xiaoyu Han, Weijun Yao, Yixin Lu. “Asymmetric Construction of Functionalized Bicyclic imides via [3+2] Annulation of MBH Carbonates Catalyzed by Dipeptide-based Phosphines”Org. Lett. 2012, 14, 3764.

16. Fangrui Zhong, Xiaoyu Han, Youqing Wang, Yixin Lu. “Highly Enantioselective [3+2] Annulation of Morita-Baylis-Hillman Adducts Mediated by L-Threonine Derived Bifunctional Phosphines: Creation of 3-Spirocyclopentene-2-oxindoles with Two Consecutive Quaternary Centers”,Angew. Chem. Int. Ed. 2011, 50, 7837. (highlighted in SYNFACTS2011, 1020)

17. Fangrui Zhong, Youqing Wang, Xiaoyu Han, Kuo-Wei Huang, Yixin Lu. “L-Threonine-Derived Bifunctional Phosphine-Sulfonamide Catalyst-Promoted Enantioselective Aza-Morita-Baylis-Hillman Reaction”,Org. Lett. 2011, 13, 1310. (highlighted in SYNFACTS 2011, 551)

18. Fangrui Zhong, Guo-Ying Chen, Yixin Lu. “Enantioselective Morita-Baylis-Hillman Reaction of Isatins with Acrylates: Facile Creation of 3-Hydroxy-2-Oxindoles”,Org. Lett. 2011, 13, 82.

19. Xiaoyu Han, Youqing Wang, Fangrui Zhong, Yixin Lu. “Enantioselective [3 + 2] Cycloaddition of Allenes to Acrylates Catalyzed by Dipeptide-derived Novel Phosphines: Facile Creation of Functionalized Cyclopentenes Containing Quaternary Stereogenic Centers”,J. Am. Chem. Soc. 2011, 133, 1726.

20. Guo-Ying Chen, Fangrui Zhong, Yixin Lu. “Highly Enantioselective and Regiospecific Substitution of Morita-Baylis-Hillman Carbonates with Nitroalkanes”Org. Lett. 2011, 13, 6070.

21. Xiao Han, Fangrui Zhong, Yixin Lu. “Highly Enantioselective Amination Reactions of Fluorinated Ketoesters Catalyzed by Novel Chiral Guanidines Derived from Cinchona Alkaloids”,Adv. Synth. Catal. 2010, 352, 2778.


  • 教育经历Education Background
  • 工作经历Work Experience
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