21) Zheng Y, Huang Q, Fang X, Xie Y*; "Route to Functionalized Tetrahydrobenzo[d]azepines via Re2O7‑Mediated Intramolecular Friedel−Crafts Reaction"; J. Org. Chem.; 2024; 89; 2001-2008.
Release time:2024-03-19
Hits:
- Indexed by:
- Journal paper
- Journal:
- The Journal of Organic Chemistry
- Included Journals:
- SCI
- Affiliation of Author(s):
- 华中科技大学
- Place of Publication:
- 美国
- Discipline:
- Science
- Funded by:
- 国家自然科学基金
- Volume:
- 89
- Page Number:
- 2001-2008
- ISSN No.:
- 0022-3263
- DOI number:
- 10.1021/acs.joc.3c01977
- Date of Publication:
- 2024-01-22
- Abstract:
- We describe a Re2O7-mediated intramolecular dehydrative Friedel−Crafts reaction for the efficient synthesis of various benzo-fused heterocycles such as benzazepines and benzazocines. This process is characterized by a broad substrate scope, mild reaction conditions, high efficiency, and high atom economy. The potential application of this methodology was exemplified by the facile preparation of a NMDA antagonist as well as a key intermediate en route to SKF 38393.
- Links to published journals:
- https://doi.org/10.1021/acs.joc.3c01977
- Pre One:22) Hu L, Xiang Y, Lan X-B, Xie Y*; "An Intermolecular Hydroarylation of Unactivated Arylcyclopropane via Re2O7/HFIP-Mediated Ring Opening"; Org. Lett.; 2024; 26; 2085-2089.
- Next One:20) Gul R, Hu L, Liu Y, Xie Y*; "Synthesis of 1-Aryltetralins via Re2O7/HReO4 Mediated Intramolecular Hydroarylations"; J. Org. Chem.; 2023; 88; 12079-12086.