22) Hu L, Xiang Y, Lan X-B, Xie Y*; "An Intermolecular Hydroarylation of Unactivated Arylcyclopropane via Re2O7/HFIP-Mediated Ring Opening"; Org. Lett.; 2024; 26; 2085-2089.
Release time:2024-03-19
Hits:
- Indexed by:
- Journal paper
- Journal:
- Organic Letters
- Included Journals:
- SCI
- Affiliation of Author(s):
- 华中科技大学
- Place of Publication:
- 美国
- Discipline:
- Science
- First-Level Discipline:
- Chemistry
- Funded by:
- 国家自然科学基金
- Volume:
- 26
- Page Number:
- 2085-2090
- ISSN No.:
- 1523-7060
- DOI number:
- 10.1021/acs.orglett.4c00272
- Date of Publication:
- 2024-03-05
- Abstract:
- In this paper, we describe a Re2O7-mediated ring-opening arylation of unactivated arylcyclopropane because of its functionalization with various arenes via Friedel−Crafts-type reactivity. This protocol allows facile access to functionalized 1,1-diaryl alkanes and is characterized by a broad substrate scope, mild reaction conditions, high efficiency, and high atom economy. Both density functional theory calculations and deuterium labeling experiments were carried out to justify the indispensable role of HFIP in this transformation and pointed to Re2O7-mediated ring opening being the rate-determining step.
- Links to published journals:
- https://doi.org/10.1021/acs.orglett.4c00272
- Pre One:23) Zheng Y, Hu Q-Q, Huang Q, Xie Y*; "Late-Stage C−H Nitration of Unactivated Arenes by Fe(NO3)3·9H2O in Hexafluoroisopropanol"; Org. Lett.; 2024; 26; 3316-3320.
- Next One:21) Zheng Y, Huang Q, Fang X, Xie Y*; "Route to Functionalized Tetrahydrobenzo[d]azepines via Re2O7‑Mediated Intramolecular Friedel−Crafts Reaction"; J. Org. Chem.; 2024; 89; 2001-2008.