论文类型：

期刊论文

发表刊物：

The Journal of Organic Chemistry

收录刊物：

SCI

所属单位：

华中科技大学

刊物所在地：

美国

学科门类：

理学

项目来源：

国家自然科学基金

卷号：

89

页面范围：

2001-2008

ISSN号：

0022-3263

DOI码：

10.1021/acs.joc.3c01977

发表时间：

2024-01-22

摘要：

We describe a Re2O7-mediated intramolecular dehydrative Friedel−Crafts reaction for the efficient synthesis of various benzo-fused heterocycles such as benzazepines and benzazocines. This process is characterized by a broad substrate scope, mild reaction conditions, high efficiency, and high atom economy. The potential application of this methodology was exemplified by the facile preparation of a NMDA antagonist as well as a key intermediate en route to SKF 38393.

发布期刊链接：

https://doi.org/10.1021/acs.joc.3c01977