论文类型：

期刊论文

发表刊物：

Organic Letters

收录刊物：

SCI

所属单位：

华中科技大学

刊物所在地：

美国

学科门类：

理学

一级学科：

化学

项目来源：

国家自然科学基金

卷号：

26

页面范围：

2085-2090

ISSN号：

1523-7060

DOI码：

10.1021/acs.orglett.4c00272

发表时间：

2024-03-05

摘要：

In this paper, we describe a Re2O7-mediated ring-opening arylation of unactivated arylcyclopropane because of its functionalization with various arenes via Friedel−Crafts-type reactivity. This protocol allows facile access to functionalized 1,1-diaryl alkanes and is characterized by a broad substrate scope, mild reaction conditions, high efficiency, and high atom economy. Both density functional theory calculations and deuterium labeling experiments were carried out to justify the indispensable role of HFIP in this transformation and pointed to Re2O7-mediated ring opening being the rate-determining step.

发布期刊链接：

https://doi.org/10.1021/acs.orglett.4c00272