23) Zheng Y, Hu Q-Q, Huang Q, Xie Y*; "Late-Stage C−H Nitration of Unactivated Arenes by Fe(NO3)3·9H2O in Hexafluoroisopropanol"; Org. Lett.; 2024; 26; 3316-3320.
发布时间：2024-04-24
点击次数：
- 论文类型：
- 期刊论文
- 发表刊物：
- Organic Letters
- 收录刊物：
- SCI
- 学科门类：
- 理学
- 卷号：
- 26
- 页面范围：
- 3316-3320
- ISSN号：
- 1523-7060
- DOI码：
- 10.1021/acs.orglett.4c01006
- 发表时间：
- 2024-04-10
- 摘要：
- Operationally simple and generally applicable arene nitration with cheap and easily accessible chemicals has been a long sought transformation in the synthetic organic community. In this work, we realized this goal with nontoxic and inexpensive Fe(NO3)3·9H2O as the nitro source and easily recyclable solvent hexafluoroisopropanol as the promotor via a network of hydrogen-bonding interactions. As a result of the relative mildness and high reliability of this protocol, late-stage nitration of various highly functionalized natural products and commercially available drugs was realized.