Indexed by:Journal paper

Correspondence Author:Liang Luo

Journal:Advanced Materials

Included Journals:SCI

Volume:32

Issue:43

Page Number:2004685

ISSN No.:0935-9648

DOI number:10.1002/adma.202004685

Date of Publication:2020-09-22

Impact Factor:27.398

Abstract:Near-infrared (NIR) chemiluminescence (CL) emission is highly favorable for deep-tissue imaging, but chemically conjugated NIR CL emitters with the aggregation-induced emission (AIE) property for biotechnology are seldom reported. Herein, an AIE-active NIR CL emitter, TBL, is synthesized by conjugating luminol unit with electron-accepting benzothiadiazole and an electrondonating triphenylamine, and subsequently TBL dots are prepared by using F127 as the surfactant. The CL emission of TBL dots can last continuously for over 60 min and can be employed for quantitative (in vitro) and qualitative (in vivo) detection of 1O2. Strikingly, the NIR CL emission can penetrate through tissues with a total thickness of over 3 cm, exhibiting significantly better performance than NIR fluorescence emission and blue CL emission.Moreover, the successful differentiation of tumor and normal tissues by TBLbased CL imaging in vivo also paves the way for CL-guided cancer diagnosis and surgery.

Links to published journals:https://onlinelibrary.wiley.com/doi/10.1002/adma.202004685