Journal:Nano letters

Included Journals:SCI

Volume:22

Issue:11

Page Number:4544-4551

Key Words:multiplexed Raman probes, Raman imaging, polydiacetylenes, isotopic doping, information storage and encryption

DOI number:10.1021/acs.nanolett.2c01443

Date of Publication:2022-05-23

Impact Factor:11.189

Abstract:Raman-based super multiplexing has attracted great interest in imaging, biological analysis, identity security, and information storage. It still remains a great challenge to synthesize a large number of different Raman-active molecules to fulfill the Raman color palette. Here, we report a facile and systematic strategy to construct continuously multiplexed ultrastrong Raman probes. By precisely incorporating different ratios of 13C isotope into the backbone of poly(deca-4,6-diynedioic acid) (PDDA), we can obtain a library of PDDAs with tunable double-bond Raman frequencies and adjustable intensity ratios of two triple-bond (13C≡13C and 12C≡12C) Raman peaks, while retaining the ultrastrong Raman signals and physicochemical properties of the polymer. We also demonstrate the successful application of 13Cdoped PDDAs as security inks to generate a novel 3D matrix barcode system for information encryption and high-density data storage. The isotopically doped PDDA series herein pave a new way to advance Raman-based super multiplexing for diverse applications.

Links to published journals:https://doi.org/10.1021/acs.nanolett.2c01443