个人信息
Personal information
教授 博士生导师 硕士生导师
性别:女
在职信息:在职
所在单位:公共卫生学院
学历:研究生(博士)毕业
学位:医学博士学位
毕业院校:华中科技大学
学科:流行病与卫生统计学个人简介
2007年毕业于华中科技大学预防医学专业,2012年在华中科技大学同济医学院获医学博士学位。现为华中科技大学公共卫生学院教授,博士生导师。2016.1-2017.12在哈佛大学医学院Dana-Farber Cancer Institute及哈佛大学公共卫生学院做博士后研究,具有大队列数据分析及管理经验。主要研究方向:营养流行病学、肿瘤流行病学。已发表SCI论文近30篇,总IF超过200分,其中以第一作者或通讯作者在JAMA,Gastroenterology, Gut, Br J Sports Med, J Am Soc Nephrol,Clin Gastroenterol Hepatol, Eur J Epidemiol, Environ Int, Cancer,等杂志上发表论文。获得湖北省科技进步二等奖(第二完成人),中国抗癌协会科技奖二等奖(第三完成人)。现担任Clinical Cancer Research, EbioMedicine, PLoS One 等杂志的审稿人。
主要承担的科研项目
2014-2016 全基因组表达相关拷贝数变异在结直肠癌发生发展中的作用及机制研究,国家自然基金青年基金 (81302491)
2014-2016 全基因组表达相关拷贝数变异在结直肠癌易感性中的作用,教育部博士点课题
2019-2020 粪便微生物检测在结直肠肿瘤早期筛查及预后预测中的价值,湖北省卫生计生科研项目青年人才项目
2019-2022 武汉市饮用水污染物全耦合多维度时空动态分析及健康风险评估,湖北省卫生健康委预防转项-重点项目
2020-2021 各项公共卫生干预措施对武汉市COVID-19疫情防控的效果评估,武汉市卫生健康委-重大项目
2020-2021 不同人群和社会场景下的新冠肺炎病毒传播特征及趋势分析,中国科协
2022-2025 炎性膳食模式、淋巴细胞浸润相关遗传变异及其交互作用与结直肠癌风险的关联及机制研究, 国家自然基金面上项目 (82173602)
主要参与的科研项目
2019-2021 结直肠癌及乳腺癌精准预防和预后评估的关键技术研发 湖北省技术创新专项重大项目
2010-2015中国农村地区传染病整合监测系统:为资源匮乏地区疾病流行的早期发现收集证据,欧盟第七框架计划项目 (241900)
2015-2019线粒体动力学改变在氟神经毒性中的作用及白藜芦醇干预效果研究,国家自然基金重点项目 (81430076)
2014-2017遗传易感性和早期生活方式的交互作用在婴儿肥胖发生中的作用,国家自然基金面上项目 (81373017)
2012-2015 Wnt信号通路及其关键靶基因与结直肠癌遗传易感性的关联研究,国家自然基金面上项目 (81172752)
2012-2014 妊娠期骨骼铅动员的MTFHR、VDR基因多态性及相关因素研究,国家自然基金青年基金 (81102185)
2012-2014 钾离子信号网络基因遗传变异与注意缺陷多动障碍易感性研究,国家自然基金青年基金 (81101016)
代表性论著
1. Pan A, Liu L, Wang C, Guo H, Hao X, Wang Q, Huang J, He N, Yu H, Lin X, Wei S, Wu T. Association of Public Health Interventions With the Epidemiology of the COVID-19 Outbreak in Wuhan, China. JAMA. 2020 Apr 10;323(19):1-9. (Co-first author)
2. Xiong F, Tang H, Liu L, Tu C, Tian J, Lei C, Liu J, Dong J, Chen W, Wang X, Luo D, Shi M, Miao X and Zhang C. Clinical Characteristics of and Medical Interventions for COVID-19 in Hemodialysis Patients in Wuhan, China. J Am Soc Nephrol. 2020 Jul;31(7):1387-1397. (Co-first author)
3. Liu L, Nishihara R, Qian ZR, Tabung FK, Nevo D, Zhang X, Song M, Cao Y, Mima K, Masugi Y, Shi Y, da Silva A, Twombly T, Gu M, Li W, Hamada T, Kosumi K, Inamura K, Nowak JA, Drew DA, Lochhead P, Nosho K, Wu K, Wang M, Garrett WS, Chan AT, Fuchs CS, Giovannucci EL, Ogino S. Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor. Gastroenterology. 2017 Dec;153(6):1517-1530.e14.
4. Yang W, Liu L, Masugi Y, Qian ZR, Nishihara R, Keum N, Wu K, Smith-Warner S, Ma Y, Nowak JA, Momen-Heravi F, Zhang L, Bowden M, Morikawa T, Silva AD, Wang M, Chan AT, Fuchs CS, Meyerhardt JA, Ng K, Giovannucci E, Ogino S, Zhang X. Calcium intake and risk of colorectal cancer according to expression status of calcium-sensing receptor (CASR). Gut. 2018 Aug;67(8):1475-1483. (co-first author)
5. Li T, Wei S, Shi Y, Pang S, Qin Q, Yin J, Deng Y, Chen Q, Wei S, Nie S, Liu L. The dose-response effect of physical activity on cancer mortality: findings from 71 prospective cohort studies. Br J Sports Med. 2016 Mar;50(6):339-45.
6. Liu L, Shi Y, Li T, Qin Q, Yin J, Pang S, Nie S, Wei S. Leisure time physical activity and cancer risk: evaluation of the WHO's recommendation based on 126 high-quality epidemiological studies. Br J Sports Med. 2016 Mar;50(6):372-8.
7. Liu L, Tabung FK, Zhang X, Nowak JA, Qian ZR, Hamada T, Nevo D, Bullman S, Mima K, Kosumi K, da Silva A, Song M, Cao Y, Twombly TS, Shi Y, Liu H, Gu M, Koh H, Li W, Du C, Chen Y, Li C, Li W, Mehta RS, Wu K, Wang M, Kostic AD, Giannakis M, Garrett WS, Hutthenhower C, Chan AT, Fuchs CS, Nishihara R, Ogino S, Giovannucci EL. Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum. Clin Gastroenterol Hepatol. 2018 Oct;16(10):1622-1631.e3.
8. Yu X, Chen J, Li Y, Liu H, Hou C, Zeng Q, Cui Y, Zhao L, Li P, Zhou Z, Pang S, Tang S, Tian K, Zhao Q, Dong L, Xu C, Zhang X, Zhang S, Liu L, Wang A. Threshold effects of moderately excessive fluoride exposure on children's health: A potential association between dental fluorosis and loss of excellent intelligence. Environ Int. 2018 Sep;118:116-124. (Co-corresponding author)
9. Hamada T, Liu L, Nowak JA, Mima K, Cao Y, Ng K, Twombly TS, Song M, Jung S, Dou R, Masugi Y, Kosumi K, Shi Y, da Silva A, Gu M, Li W, Keum N, Wu K, Nosho K, Inamura K, Meyerhardt JA, Nevo D, Wang M, Giannakis M, Chan AT, Giovannucci EL, Fuchs CS, Nishihara R, Zhang Z, Ogino S. Vitamin D status after colorectal cancer diagnosis and patient survival according to immune response to tumour. Eur J Cancer. 2018 Sep 12;103:98-107. (co-first author)
10. Kosumi K, Hamada T, Zhang S, Liu L, da Silva A, Koh H, Twombly TS, Mima K, Morikawa T, Song M, Nowak JA, Nishihara R, Saltz LB, Niedzwiecki D, Ou FS, Zemla T, Mayer RJ, Baba H, Ng K, Giannakis M, Zhang X, Wu K, Giovannucci EL, Chan AT, Fuchs CS, Meyerhardt JA, Ogino S. Prognostic association of PTGS2 (COX-2) over-expression according to BRAF mutation status in colorectal cancer: Results from two prospective cohorts and CALGB 89803 (Alliance) trial. Eur J Cancer. 2019 Apr;111:82-93. (co-first author)
11. Liu L, Nevo D, Nishihara R, Cao Y, Song M, Twombly TS, Chan AT, Giovannucci EL, VanderWeele TJ, Wang M, Ogino S.Utility of inverse probability weighting in molecular pathological epidemiology. Eur J Epidemiol. 2018 Apr;33(4):381-392.
12. Liu L, Wu J, Wu C, Zhong R, Zhang X, Tan W, Nie S, Miao X, Lin D. A functional polymorphism (-1607 1G→2G) in the matrix metalloproteinase-1 promoter is associated with development and progression of lung cancer. Cancer. 2011 Nov 15;117(22):5172-81.
13. Shi Y, Li T, Wang Y, Zhou L, Qin Q, Yin J, Wei S, Liu L, Nie S. Household physical activity and cancer risk: a systematic review and dose-response meta-analysis of epidemiological studies. Sci Rep. 2015 Oct 7;5:14901. (co-corresponding author)
14. Liu L, Yuan P, Liu L, Wu C, Zhang X, Guo H, Zhong R, Xu Y, Wu J, Duan S, Rui R, Wu T, Nie S, Miao X, Lin D. A functional -77T>C polymorphism in XRCC1 is associated with risk of breast cancer. Breast Cancer Res Treat. 2011 Jan;125(2):479-87.
15. Chen D, Liu L, Xiao Y, Peng Y, Yang C, Wang Z. Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol dependence among Asians and Caucasians. Drug and Alcohol Dependence. 2012 Jun 1;123(1-3):1-6. (Co-first author)
16. Wang K, Yu X, Jiang H, Huang J, Wang H, Jiang H, Wei S, Liu L. Genome-wide expression profiling-based copy number variations and colorectal cancer risk in Chinese. Mol Carcinog. 2019 Jul;58(7):1324-1333.
17. Liu L, Wu J, Zhong R, Wu C, Zou L, Yang B, Chen W, Zhu B, Duan S, Yu D, Tan W, Nie S, Lin D, Miao X. Multi-loci analysis reveals the importance of genetic variations in sensitivity of platinum-based chemotherapy in non-small-cell lung cancer. Mol Carcinog. 2013 Dec;52(12):923-31.
18. Pang S, Zhou Z, Yu X, Wei S, Chen Q, Nie S, Liang X, Liu L.The predictive value of integrated inflammation scores in the survival of patients with resected hepatocellular carcinoma: A Retrospective Cohort Study. Int J Surg. 2017 Jun;42:170-177.
19. Tabung FK, Liu L, Wang W, Fung TT, Wu K, Smith-Warner SA, Cao Y, Hu FB, Ogino S, Fuchs CS, Giovannucci EL. Association of Dietary Inflammatory Potential With Colorectal Cancer Risk in Men and Women. JAMA Oncol. 2018 Mar 1;4(3):366-373.
20. Hamada T, Cao Y, Qian ZR, Masugi Y, Nowak JA, Yang J, Song M, Mima K, Kosumi K, Liu L, Shi Y, da Silva A, Gu M, Li W, Keum N, Zhang X, Wu K, Meyerhardt JA, Giovannucci EL, Giannakis M, Rodig SJ, Freeman GJ, Nevo D, Wang M, Chan AT, Fuchs CS, Nishihara R, Ogino S. Aspirin Use and Colorectal Cancer Survival According to Tumor CD274 (Programmed Cell Death 1 Ligand 1) Expression Status. J Clin Oncol. 2017 Jun 1;35(16):1836-1844.