田斯丹

613

性别:男

在职信息:在职

所在单位:生命科学与技术学院

学历:研究生(博士)毕业

学位:理学博士学位

学科:生物医学工程

查看更多>

Reactive oxygen species-responsive and Raman-traceable hydrogel combining photodynamic and immune therapy for postsurgical cancer treatment

发布时间:2023-07-17 点击次数:

论文类型:文章

发表刊物:Nature Communications

收录刊物:SCI

卷号:13

ISSN号:2041-1723

DOI码:10.1038/s41467-022-32160-z

发表时间:2022-08-04

影响因子:14.919

摘要:Combining immune checkpoint blockade (ICB) therapy with photodynamic therapy (PDT) holds great potential in treating immunologically “cold” tumors, but photo-generated reactive oxygen species (ROS) can inevitably damage co-administered ICB antibodies, hence hampering the therapeutic outcome. Here we create a ROS-responsive hydrogel to realize the sustained co-delivery of photosensitizers and ICB antibodies. During PDT, the hydrogel skeleton poly(deca-4,6-diynedioic acid) (PDDA) protects ICB antibodies by scavenging the harmful ROS, and at the same time, triggers the gradual degradation of the hydrogel to release the drugs in a controlled manner. More interestingly, we can visualize the ROS-responsive hydrogel degradation by Raman imaging, given the ultrastrong and degradation-correlative Raman signal of PDDA in the cellular silent window. A single administration of the hydrogel not only completely inhibits the long-term postoperative recurrence and metastasis of 4T1-tumor-bearing mice, but also effectively restrains the growth of re-challenged tumors. The PDDA-based ROS-responsive hydrogel herein paves a promising way for the durable synergy of PDT and ICB therapy.

发布期刊链接:https://www.nature.com/articles/s41467-022-32160-z

地址:湖北省武汉市洪山区珞喻路1037号 邮政编码:430074

访问量: | 开通时间:-- | 最后更新时间:-- 手机版