Indexed by: Unit Twenty Basic Research

Document Code: PMID: 20161747

First Author: Xiaoyang Wan

Correspondence Author: Wuhan Xiao

Co-author: Wei Ji, Xue Mei, Jiangang Zhou, Jing-xia Liu, Chengchi Fang, Wuhan Xiao

Journal: PloS One

Included Journals: SCI

Affiliation of Author(s): Institute of Hydrobiology, Chinese Academy of Sciences

Place of Publication: USA

Discipline: Science

First-Level Discipline: Biology

Document Type: R

Volume: 5

Issue: (2)

Page Number: e9118

Date of Publication: 2010-02-09

Abstract: Previous studies indicated that EAF (ELL-associated factor) family members, EAF1 and EAF2/U19, play a role in cancer and embryogenesis. For example, EAF2/U19 may serve as a tumor suppressor in prostate cancer. At the same time, EAF2/U19 is a downstream factor in the non-canonical Wnt 4 signaling pathway required for eye development in Xenopus laevis, and along with EAF1, contributes to convergence and extension movements in zebrafish embryos through Wnt maintenance. Here, we used zebrafish embryos and mammalian cells to show that both EAF1 and EAF2/U19 were up-regulated by Wnt4 (Wnt4a). Furthe

Links to published journals: https://www.ncbi.nlm.nih.gov/pubmed/20161747