Indexed by: Unit Twenty Basic Research

Document Code: PMID: 21784840

First Author: Xiaoyang Wan

Correspondence Author: Wuhan Xiao

Co-author: Bo Hu, Jing-xia Liu, Xi Feng

Journal: the Journal of Biological Chemistry

Included Journals: SCI

Affiliation of Author(s): Institute of Hydrobiology, Chinese Academy of Sciences

Discipline: Science

First-Level Discipline: Biology

Volume: 286

Issue: (38)

Page Number: 33345-57

ISSN No.: 1083-351X

Date of Publication: 2011-09-23

Abstract: Studies implicate an important role for the mixed lineage leukemia (Mll) gene in hematopoiesis, mainly through maintaining Hox gene expression. However, the mechanisms underlying Mll-mediated hematopoiesis during embryogenesis remain largely unclear. Here, we investigate the role of mll during zebrafish embryogenesis, particularly hematopoiesis. Mll depletion caused severe defects in hematopoiesis as indicated by a lack of blood flow and mature blood cells as well as a significant reduction in expression of hematopoietic progenitor and mature blood cell markers. Furthermore, mll depletion prev

Links to published journals: https://www.ncbi.nlm.nih.gov/pubmed/21784840