Indexed by: Unit Twenty Basic Research

Document Code: PMID: 26794661

First Author: Zhaohong Chen

Correspondence Author: Zhihong Liu

Journal: Cell Death & Disease

Included Journals: SCI

Place of Publication: US

Discipline: Science

First-Level Discipline: Biology

Volume: 7

Issue: (1)

Page Number: e2068

ISSN No.: 2041-4889

Date of Publication: 2016-01-07

Abstract: GADD45 gene has been implicated in cell cycle arrest, cell survival or apoptosis in a cell type specific and context-dependent manner. Members of GADD45 gene family have been found differentially expressed in several podocyte injury models, but their roles in podocytes are unclear. Using an in vivo zebrafish model of inducible podocyte injury that we have previously established, we found that zebrafish orthologs of gadd45b were induced upon the induction of podocyte injury. Podocyte-specific overexpression of zebrafish gadd45b exacerbated edema, proteinuria and foot-process effacement, whereas

Links to published journals: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816163/