Indexed by: Unit Twenty Basic Research

Document Code: PMID: 29551191

Correspondence Author: Qin Ning

Journal: Cellular Immunology

Included Journals: SCI

Affiliation of Author(s): Huazhong University of Science and Technology

Place of Publication: USA

Discipline: Medicine

First-Level Discipline: Basic Medicine

Volume: S0008-8749

Issue: (17)

Page Number: 30235-6

ISSN No.: 0008-8749

Date of Publication: 2017-12-11

Abstract: Autoimmune hepatitis (AIH) is a chronic autoimmune disease with the primary focus on autoreactive Th1-mediated response and cytotoxic T cells reaction. The contribution of natural killer cells (NK cells) to AIH remains poorly understood. In this project, we revealed that the frequency of peripheral NK cells, more accurately CD56dimNK subset, was reduced in AIH patients. The reduction of CD56dimNK was negatively correlated with disease progression. In experimental autoimmune hepatitis (EAH), hepatic accumulation of NK cells is observed along with a decrease of NK cells in the periphery. In addi

Links to published journals: https://www.ncbi.nlm.nih.gov/pubmed/29551191