Negative Feedback Regulation of Wnt4 Signaling by EAF1 and EAF2/U19
论文类型：基础研究
论文编号：PMID: 20161747
第一作者：Xiaoyang Wan
通讯作者：Wuhan Xiao
合写作者： Wei Ji, Xue Mei, Jiangang Zhou, Jing-xia Liu, Chengchi Fang, Wuhan Xiao
发表刊物：PloS One
收录刊物：SCI
所属单位：Institute of Hydrobiology, Chinese Academy of Sciences
刊物所在地：USA
学科门类：理学
一级学科：生物学
文献类型：R
卷号：5
期号：(2)
页面范围：e9118
发表时间：2010-02-09
摘要：Previous studies indicated that EAF (ELL-associated factor) family members, EAF1 and EAF2/U19, play a role in cancer and embryogenesis. For example, EAF2/U19 may serve as a tumor suppressor in prostate cancer. At the same time, EAF2/U19 is a downstream factor in the non-canonical Wnt 4 signaling pathway required for eye development in Xenopus laevis, and along with EAF1, contributes to convergence and extension movements in zebrafish embryos through Wnt maintenance. Here, we used zebrafish embryos and mammalian cells to show that both EAF1 and EAF2/U19 were up-regulated by Wnt4 (Wnt4a). Furthe