论文类型：基础研究

论文编号：PMID: 21784840

第一作者：Xiaoyang Wan

通讯作者：Wuhan Xiao

合写作者： Bo Hu, Jing-xia Liu, Xi Feng

发表刊物：the Journal of Biological Chemistry

收录刊物：SCI

所属单位：Institute of Hydrobiology, Chinese Academy of Sciences

学科门类：理学

一级学科：生物学

卷号：286

期号：(38)

页面范围：33345-57

ISSN号：1083-351X

发表时间：2011-09-23

摘要：Studies implicate an important role for the mixed lineage leukemia (Mll) gene in hematopoiesis, mainly through maintaining Hox gene expression. However, the mechanisms underlying Mll-mediated hematopoiesis during embryogenesis remain largely unclear. Here, we investigate the role of mll during zebrafish embryogenesis, particularly hematopoiesis. Mll depletion caused severe defects in hematopoiesis as indicated by a lack of blood flow and mature blood cells as well as a significant reduction in expression of hematopoietic progenitor and mature blood cell markers. Furthermore, mll depletion prev

发布期刊链接：https://www.ncbi.nlm.nih.gov/pubmed/21784840