The construction of intrahepatic cholangiocarcinoma model in zebrafish.
论文类型：基础研究
论文编号：PMID: 29042681
第一作者：Jing Wang
通讯作者：Hong Cao
发表刊物：Scientific Reports
收录刊物：SCI
所属单位：Institute of Hydrobiology, Chinese Academy of Sciences
刊物所在地：British
学科门类：医学
一级学科：基础医学
卷号：7
期号：(1)
页面范围：13419
ISSN号：0068-1261
发表时间：2017-10-17
摘要：Intrahepatic cholangiocarcinoma (ICC) is a highly malignant tumor, difficult to diagnose even at an early stage. In this study, we successfully constructed an nras61K-induced ICC model in zebrafish. Transcriptome analysis and gene set enrichment analysis (GSEA) of liver samples of the ICC and WT (wild-type) zebrafish revealed that the genes differentially expressed between the two groups were mainly involved in focal adhesion, chemokine signaling and metabolic pathways. Analysis of DNA methylomes revealed that compared with WT samples, methylated genes in ICC samples were enriched in functions