Intrahepatic recruitment of cytotoxic NK cells contributes to autoimmune hepatitis progression.
论文类型：基础研究
论文编号：PMID: 29551191
通讯作者：Qin Ning
发表刊物：Cellular Immunology
收录刊物：SCI
所属单位：Huazhong University of Science and Technology
刊物所在地：USA
学科门类：医学
一级学科：基础医学
卷号：S0008-8749
期号：(17)
页面范围：30235-6
ISSN号：0008-8749
发表时间：2017-12-11
摘要：Autoimmune hepatitis (AIH) is a chronic autoimmune disease with the primary focus on autoreactive Th1-mediated response and cytotoxic T cells reaction. The contribution of natural killer cells (NK cells) to AIH remains poorly understood. In this project, we revealed that the frequency of peripheral NK cells, more accurately CD56dimNK subset, was reduced in AIH patients. The reduction of CD56dimNK was negatively correlated with disease progression. In experimental autoimmune hepatitis (EAH), hepatic accumulation of NK cells is observed along with a decrease of NK cells in the periphery. In addi