论文类型：基础研究

论文编号：PMID: 26794661

第一作者：Zhaohong Chen

通讯作者：Zhihong Liu

发表刊物：Cell Death & Disease

收录刊物：SCI

刊物所在地：US

学科门类：理学

一级学科：生物学

卷号：7

期号：(1)

页面范围：e2068

ISSN号：2041-4889

发表时间：2016-01-07

摘要：GADD45 gene has been implicated in cell cycle arrest, cell survival or apoptosis in a cell type specific and context-dependent manner. Members of GADD45 gene family have been found differentially expressed in several podocyte injury models, but their roles in podocytes are unclear. Using an in vivo zebrafish model of inducible podocyte injury that we have previously established, we found that zebrafish orthologs of gadd45b were induced upon the induction of podocyte injury. Podocyte-specific overexpression of zebrafish gadd45b exacerbated edema, proteinuria and foot-process effacement, whereas

发布期刊链接：https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816163/