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个人简介Personal Profile
2025年招收具有合成生物学、人工酶、非天然氨基酸表达、人工智能蛋白设计方面研究背景的博士后2-3名。详细信息请参见：https://postdoctor.hust.edu.cn/info/1007/3342.htm
个人介绍
吴钰周，华中科技大学化学与化工学院教授、副院长、生物无机化学与药物湖北省重点实验室主任、生物医用与防护材料湖北省工程研究中心副主任、国家重点研发计划青年项目负责人、德国马普协会“国际合作伙伴小组”负责人。2008年本科毕业于浙江大学，2010年硕士毕业于新加坡国立大学，2013年于德国乌尔姆大学Tanja Weil教授课题组获得博士学位。2013-2016年间先后担任德国乌尔姆大学和马普高分子所课题组长。2016年加入华中科技大学任教授。入选国家级高层次青年人才计划，湖北省百名优秀女性科技创新人才。担任Science Bulletins期刊特邀编委、湖北省合成生物学会理事。
吴钰周教授主要从事超越自然进化的生物合成研究。基于合成生物学的生物制造技术作为绿色生产力的代表，被认为是未来最具有影响力的前沿技术之一。然而，目前生物制造能够应用的领域非常有限，主要局限于天然产物的生产，远不能满足大量非天然化学品的合成需求。其根本原因是天然酶的反应类型有限，无法提供化学合成所需要的丰富的催化模式。人工设计具有目标催化活性的酶，实现更多非天然化学品的生物制造，有望为化工、医药、材料等各领域的发展带来绿色变革性技术。我们的研究旨在建立融合化学催化模式和酶催化特性的人工酶构建技术，通过在酶中构建含有非天然催化基团的人工活性中心，将有机化学发展的丰富的催化模式构建在酶的活性空腔内，再通过蛋白设计与定向进化实现蛋白结构与非天然反应中心的适配，从而构建超越天然酶催化机制的人工酶。在此基础上，实现人工酶与天然酶代谢通路的偶联，将人工酶发展成为生物合成的重要工具元件，从而打通非天然产物生物制造的瓶颈，为实现绿色生物制造在工业生产中的广泛应用奠定重要的底层技术。基于人工酶合成生物系统，发展药物合成和靶向递送新方法、生物合成新材料等，为医药健康领域提供创新技术。
吴钰周教授主持了多项国家重点研发计划项目、国家自然科学基金项目和湖北省重点研发计划项目，在Nature, J. Am. Chem. Soc.，Angew. Chem. Int. Ed., Nat. Commun.等国际权威期刊发表论文150余篇，参编学术专著4章，授权发明专利十余项。研究成果入选成果被科技部网站、人民日报、光明日报等广泛报道，入选湖北省科协优秀科技论文奖、华中科技大学2023年度重大学术进展，并作为重要支撑成果入选湖北省科技进步特等奖。
研究方向
1）人工酶设计构建与非天然生物合成
2）合成生物学生物医用材料
代表性论文
1. Ningning Sun, Jianjian Huang, Junyi Qian, Taiping Zhou, Juan Guo, Langyu Tang, Wentao Zhang, Yaming Deng, Weining Zhao, Guojiao Wu, Rongzhen Liao, Xi Chen*, Fangrui Zhong*, Yuzhou Wu*, Enantioselective [2+2]-cycloadditions with triplet photoenzymes, Nature, 2022, https://doi.org/10.1038/s41586-022-05342-4
2. Xinjie Yang, Jianjian Huang, Juan Guo, Shuran Fang, Zhiming Wang, Guojiao Wu*, Yuzhou Wu* and Fangrui Zhong*, Chemical Society Reviews, 2025, 54, 5157-5188. https://pubs.rsc.org/en/content/articlelanding/2025/cs/d4cs00561a
3. Jinsheng Li; Weihua Qiao; Yuqi Liu; Wenyi Wan; Zian Lin; Xiang Qiu; Zhuoran Yang; Pengning Fan; Huiling Lei; Ying Zhou; Jiawei Shi*; Yuzhou Wu*; Nianguo Dong*, Constructing Immunomodulator Biosynthesis Factory in Grafting-From DNA Hydrogel for Heart Valve Regeneration, Advanced Materials, 2025, https://doi.org/10.1002/adma.202506728
4. Jinsheng Li; Weihua Qiao; Yuqi Liu; Huiling Lei; Shuangshuang Wang; Yin Xu; Ying Zhou; Shuyu Wen; Zhuoran Yang; Wenyi Wan; Jiawei Shi*; Nianguo Dong*; Yuzhou Wu*, Facile Engineering of Interactive Double Network Hydrogels for Heart Valve Regeneration, Nature Communications, 2024, 15(1): 7462. https://www.nature.com/articles/s41467-024-51773-0
5. Juan Guo; Junyi Qian; Daihong Cai; Jianjian Huang; Xinjie Yang; Ningning Sun; Junshuai Zhang; Tengfei Pang; Weining Zhao; Guojiao Wu; Xi Chen; Fangrui Zhong; Yuzhou Wu*, Chemogenetic Evolution of Diversified Photoenzymes for Enantioselective [2 + 2] Cycloadditions in Whole Cells, Journal of the American Chemical Society, 2024, 146(28): 19030-19041. https://pubs.acs.org/doi/10.1021/jacs.4c03087
6. Zi'an Lin; Xuemei Xu; Yiwei Shi; Yuzhou Wu*, Precision fabrication of polymer nanostructures on recyclable DNA template, Smart Molecules, 2024, 2, e20240006.
7. Huaibin Yu; Shuangshuang Wang; Yu Fu; Manfred Wagner; Tanja Weil; Shaoqin Liu; Weining Zhao; Fangrui Zhong; Yuzhou Wu*, Spatiotemporally Controlled Photolabeling of Genetically Unmodified Proteins in Live Cells, Analytical Chemistry, 2024, 96(5): 1930-1940
8. Yu Fu, Xiaohong Liu, Yan Xia, Xuzhen Guo, Juan Guo, Junshuai Zhang, Weining Zhao, Yuzhou Wu, Jiangyun Wang*, Fangrui Zhong*, Whole-cell-catalyzed hydrogenation/deuteration of aryl halides with a genetically repurposed photodehalogenase, Chem, 2013, 9, 1897-1909
9. Tong Zhou; Shuaiqi Yuan; Pinrong Qian; Yuzhou Wu*, Enzymes in Nanomedicine for Anti-tumor Therapy, Chemical Research in Chinese Universities, 2023, 39: 72-81
10. Huaibin Yu; Meron Tsegay Kifle; Lili Chen; Feihong Xiong; Yan Zhang; Shangbang Gao; Wei Hou; Shulian Chen; Weining Zhao*; Yuzhou Wu*, Traceless Photodegradable Polymer Cocoons for Universal Protein Delivery and Light-controlled Gene Editing, Science China Chemistry, 2024, 67(2): 664-676
11. Shuangshuang Wang; Huaibin Yu; Longjie Li; Meizhou Zhang; Yu Fu; Zi’an Lin; Jinsheng Li; Fangrui Zhong; Hongmei Liu*; Yuzhou Wu*, Fluorescent Turn-On Probes for Visualizing GPx4 Levels in Live Cells and Predicting Drug Sensitivity, Analytical Chemistry, 2023, 95(23): 8939-8947
12. Huan Guo; Ningning Sun; Juan Guo; Tai-Ping Zhou; Langyu Tang; Wentao Zhang; Yaming Deng; Rong-Zhen Liao; Yuzhou Wu; Guojiao Wu; Fangrui Zhong*, Expanding the Promiscuity of a Copper-Dependent Oxidase for Enantioselective Cross-Coupling of Indoles, Angew Chem Int Ed, 2023, 135, e202219034.
13. Tong Zhou; Shuaiqi Yuan; Pinrong Qian; Yuzhou Wu*, Enzymes in Nanomedicine for Anti-tumor Therapy, Chemical Research in Chinese Universities, 2023
14. Huaibin Yu, Shuangshuang Wang, Jianjian Huang, Yu Fu, Manfred Wagner, Tanja Weil, Fangrui Zhong, Weining Zhao*, and Yuzhou Wu*, Light-Controlled Traceless Protein Labeling via Decaging Thio-o-naphthoquinone Methide Chemistry, Org. Lett. 2022, 24, 6816.
15. Xinyu Liu; Meron Tsegay Kifle; Hongxin Xie; Liexi Xu; Maoling Luo; Yangyi Li; Zhengrong Huang; Yan Gong; Yuzhou Wu*; Conghua Xie*, Biomineralized Manganese Oxide Nanoparticles Synergistically Relieve Tumor Hypoxia and Activate Immune Response with Radiotherapy in Non-Small Cell Lung Cancer，Nanomaterials, 2022, 12(18): 3138
16. Hongxin Xie; Xinyu Liu; Zhengrong Huang; Liexi Xu; Rui Bai; Fajian He; Mengqin Wang; Linzhi Han; Zhirong Bao; Yuzhou Wu*; Conghua Xie*; Yan Gong*, Nanoscale Zeolitic Imidazolate Framework (ZIF)–8 in Cancer Theranostics: Current Challenges and Prospects, Cancers, 2022, 14(16): 3935-3935
17. Yiwei Shi, Xuemei Xu, Huaibin Yu, Zian Lin, Honghua Zuo, and Yuzhou Wu*, Defined positive charge patterns created on DNA nanostructures determine cellular uptake efficiency. Nano Lett. 2022, 22, 5330.
18. Huaibin Yu, Jiayi Feng, Fangrui Zhong, Yuzhou Wu*, Chemical Modification for the “Off-/On” Regulation of Enzyme Activity. Macromol. Rapid Commun.2022, 43, 2200195.
19. Yaming Deng, Quan Zhou, Yuzhou Wu, Xi Chen*, Fangrui Zhong*, Properties and Mechanisms of Flavin-Dependent Monooxygenases and Their Applications in Natural Product Synthesis. Int. J. Mol. Sci. 2022, 23, 2622.
20. Boyang Hu, Ruijie Liu, Qingyue Liu, Zi’an Lin, Yiwei Shi, Jun Li, Lijun Wang, Longjie Li,* Xianjin Xiao* and Yuzhou Wu*, Engineering surface patterns on nanoparticles: new insights into nano-bio interactions. J. Mater. Chem. B, 2022, 10, 2357.
21. Liandong Feng, Li Yang, Longjie Li, Junying Xiao, Nana Bie, Chao Xu, Jun Zhou, Hongmei Liu, Lu Gan, Yuzhou Wu*, Programmed albumin nanoparticles regulate immunosuppressive pivot to potentiate checkpoint blockade cancer immunotherapy, Nano Research, 2022, 15, 593-602.
22. Liu, Jin; Zhang, Meizhou; Wu, Yuzhou*, In situ synthesis of fluorescent polydopamine on biogenic MnO2 nanoparticles as stimuli responsive multifunctional theranostic, Biomaterials Science, 2021, 9(17): 5897-5906.
23. Colette J Whitfield#; Meizhou Zhang#; Pia Winterwerber; Yuzhou Wu*; David Y W Ng*; Tanja Weil*, Functional DNA-Polymer Conjugates. Chemical Reviews, 2021, 121(18): 11030-11084.
24. Jin Liu; Liandong Feng; Yuzhou Wu*, Enzymatically synthesised MnO2 nanoparticles for efficient near-infrared photothermal therapy and dual-responsive magnetic resonance imaging, Nanoscale, 2021, 13(25): 11093-11103.
25. Liandong Feng, Shanshan Wu, Yuzhou Wu*, Intracellular Bottom-up Synthesis of Ultrasmall CuS Nanodots in Cancer Cells for Simultaneous Photothermal Therapy and COX-2 Inactivation, Advanced Functional Materials, 2021, 31, 2101297
26. Zhou, Tai-Ping; Zhong, Fangrui*; Wu, Yuzhou; Liao, Rong-Zhen*, Regioselectivity and stereoselectivity of intramolecular [2+2] photocycloaddition catalyzed by chiral thioxanthone: a quantum chemical study, Organic and Biomolecular Chemistry, 2021, 19(7): 1532-1540.
27. Lu, Xunbo; Bai, Yulong; Qin, Jingyang; Wang, Nan; Wu, Yuzhou*; Zhong, Fangrui*, Alleviating Catalyst Decay Enables Efficient Intermolecular C(sp(3))-H Amination under Mechanochemical Conditions, ACS Sustainable Chemistry and Engineering, 2021, 9(4): 1684-1691.
28. Shanshan Wu#, Meizhou Zhang#, Jie Song, Stefan Weber, Xiaoguo Liu, Chunhai Fan, and Yuzhou Wu* Fine Customization of Calcium Phosphate Nanostructures with Site-Specific Modification by DNA Templated Mineralization, ACS Nano, 2021, 15, 1555–1565
29. Yu Fu, Jian Huang, Yuzhou Wu*, Xiaohong Liu*, Fangrui Zhong*, and Jiangyun Wang*, Biocatalytic Cross-Coupling of Aryl Halides with a Genetically Engineered Photosensitizer Artificial Dehalogenase, J. Am. Chem. Soc. 2021, 143, 2, 617–622
30. Zhang, Meizhou; Wang, Shuangshuang; Li, Longjie; Li, Mengran; Cheng, Xinyi; Shi, Yiwei; Wu, Yuzhou*, Digital Numbers Constructed by Fine Patterned Polydopamine on DNA Templates, Macromolecular Rapid Communications, 2021, 42(21): 0-2100441.
31. Longjie Li,‡ Wenkai Zhang,‡ Xiaofeng Tang, Zejian Li, Yuzhou Wu* and Xianjin Xiao*, Fine and bidirectional regulation of toehold-mediated DNA strand displacement by a wedge-like DNA tool, Chem. Commun., 2020, 56, 8794-8797
32. Juan Guo, Huan Guo, Jin Liu*, Fangrui Zhong and Yuzhou Wu*, Manganese(II) Oxidizing Bacteria as Whole-Cell Catalyst for β-Keto Ester Oxidation, Int. J. Mol. Sci. 2020, 21, 1709
33. Yuan Zhuang, Longjie Li, Liandong Feng, Shuangshuang Wang, Huimin Su, Haijuan Liu, Hongmei Liu*, Yuzhou Wu*, Mitochondrion-targeted selenium nanoparticles enhance reactive oxygen species-mediated cell death, Nanoscale, 2020, 12, 1389-1396.
34. Jessica Wagner, Longjie Li, Johanna Simon, Lea Krutzke, Katharina Landfester, Volker Mailänder, Klaus Müllen, David Y.W. Ng,* Yuzhou Wu*, Tanja Weil*, Amphiphilic Polyphenylene Dendron Conjugates for Surface Remodeling of Adenovirus 5, Angew. Chem. Int. Ed., 2020, 59, 5712-5720
35. So Yeon Ahn, Jin Liu, Srivithya Vellampatti, Yuzhou Wu*, Soong Ho Um*, DNA Transformations for Diagnosis and Therapy, Advanced Functional Materials, 2020, 31, 2008279
36. Wang, Dangui; Lu, Xunbo; Sun, Shaohan; Yu, Huaibin; Su, Huimin; Wu, Yuzhou*; Zhong, Fangrui*, Unified and Benign Synthesis of Spirooxindoles via Bifunctional and Recyclable Iodide-Salt-Catalyzed Oxidative Coupling in Water, European Journal of Organic Chemistry, 2019, 2019(35): 6028-6033.
37. Yu Fu, Qile Yu, Yulong Zhang, Zhonghong Gao,* Yuzhou Wu* and Fangrui Zhong*, Hemin catalyzed biomimetic oxidative phenol-indole [3+2] reactions in aqueous media, Org. Biomol. Chem., 2019,17, 9994
38. Yuzhou Wu#*, Longjie Li#, Larissa Frank#, Jessica Wagner, Patrizia Andreozzi, Brenton Hammer, Marco D’Alicarnasso, Maria Pelliccia, Weina Liu, Sabyasachi Chakrabortty, Silke Krol, Johanna Simon, Katharina Landfester, Seah Ling Kuan, Francesco Stellacci, Klaus Müllen, Florian Kreppel*, Tanja Weil*, Patchy Amphiphilic Dendrimers Bind Adenovirus and Control Its Host Interactions and in Vivo Distribution, ACS Nano, 2019, 13, 8, 8749-8759.
39. Fu, Yu; Yu, Qile; Zhang, Yulong; Gao, Zhonghong; Wu, Yuzhou*; Zhong, Fangrui*, Hemin-catalyzed biomimetic oxidative phenol-indole [3 2] reactions in aqueous media, Organic and Biomolecular Chemistry, 2019, 17(47): 9994-9998.
40. Yan Li, Longjie Li, Xunbo Lu, Yulong Bai, Yufan Wang, Yuzhou Wu*, Fangrui Zhong*, Bioinspired radical cyclization of tryptamines: synthesis of peroxypyrroloindolenines as potential anti-cancer agents, Chem. Commun., 2019, 55, 63-66.
41. Qile Yu; Yu Fu; Jianjian Huang; Jingyang Qin; Honghua Zuo; Yuzhou Wu*; Fangrui Zhong*, Enantioselective Oxidative Phenol-Indole [3+2] Coupling Enabled by Biomimetic Mn(III)/ Brønsted Acid Relay Catalysis, ACS Catalysis, 2019
42. Tanghui Duan, Liu He, Yu Tokura, Xin Liu, Yuzhou Wu*, Zhengshuang Shi*. Construction of tunable peptide nucleic acid junctions. Chem. Commun., 2018, 54, 2846-2849.
43. Yu Tokura, Sean Harvey, Yuzhou Wu,* David Y. W. Ng *, Tanja Weil *.Polymer tube nanoreactors via DNA-origami templated synthesis. Chem. Commun., 2018, 54, 2808-2811.
44. Yu Tokura, Sean Harvey, Chaojian Chen, Yuzhou Wu*, David Y. W. Ng*, Tanja Weil*, Fabrication of defined polydopamine nanostructures by DNA origami-templated polymerization, Angew. Chem. Int. Ed., 2018, 57, 1587-1591
45. Weina Liu, Felix Boldt, Yu Tokura, Tao Wang, Bikram Keshari Agrawalla, Yuzhou Wu* and Tanja Weil*, Encoding function into polypeptide-oligonucleotide precision biopolymers, Chem. Commun., 2018, 54, 11797-11800.
46. Jasmina Gačanin, Anna Kovtun, Stephan Fischer, Victoria Schwager, Johanna Quambusch, Seah Ling Kuan, Weina Liu, Felix Boldt, Chuang Li, Zhongqiang Yang, Dongsheng Liu, Yuzhou Wu,* Tanja Weil, Holger Barth,* and Anita Ignatius*, Spatiotemporally Controlled Release of Rho-Inhibiting C3 Toxin from a Protein-DNA Hybrid Hydrogel for Targeted Inhibition of Osteoclast Formation and Activity, Adv. Healthcare Mater. 2017, 6, 1700392