吴钰周

基本信息Personal Information

教授 博士生导师 硕士生导师

性别 : 女

毕业院校 : 德国乌尔姆大学

学历 : 研究生(博士)毕业

学位 : 理学博士学位

在职信息 : 在职

所在单位 : 化学与化工学院

学科 : 化学生物学

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个人简介Personal Profile

实验室最新动态请参阅课题组主页:http://bionano.chem.hust.edu.cn/

2019-2020年招收具有合成生物学、人工酶、非天然氨基酸表达、生物工程、微生物学方面研究背景的博士生及博士后2-3名,以及与华中科技大学协和医院心脏血管外科董念国教授联合诚聘现诚聘心脏瓣膜组织工程领域的基础研究博士后1-2名。详细信息请参见:http://muchong.com/t-13536957-1和 http://muchong.com/t-13577463-1


个人介绍

吴钰周,华中科技大学化学与化工学院教授,博士生导师,青年千人计划入选者。先后于浙江大学、新加坡国立大学、和德国乌尔姆大学获得学士、硕士和博士学位。20135月-20169月先后担任德国乌尔姆大学和马普高分子研究所课题组长,20169月起任华中科技大学化学与化工学院教授,兼任马普高分子研究所课题组长,2017年入选中组部第十三批青年千人计划,2019年任国家重点研发计划青年项目首席科学家。2019年吴钰周教授课题组被遴选为德国马普学会国际伙伴研究小组。

吴钰周教授主要从事功能生物大分子材料领域的研究,主要方向包括蛋白质及核酸衍生的智能生物纳米材料、纳米医药及靶向药物载体、DNA折纸材料与纳米医学和人工酶合成生物学。研究成果已在国际权威期刊发表论文60余篇,第一及通讯作者在包括J. Am. Chem. Soc.,Angew. Chem. Int. Ed., Acc. Chem. Res., Adv. Func. Mater.ACS Nano, Nano Lett.等期刊发表论文30余篇,多篇文章被选做期刊封面,并被Nature等期刊大篇幅引用评述。

吴钰周教授参与了欧盟地平线2020计划框架下的“个性化健康与治疗(PHC)”大型国际合作项目(子课题共同负责人)、德国巴登符腾堡州基金会中德合作项目(项目共同负责人)、德国科学基金会(DFG)重大专项(SFB1279)(子课题共同负责人),乌尔姆大学Forschungsbonus 课题(项目负责人),与德国乌尔姆大学医学院及德国知名药企Merck Pharmaceuticals 公司合作紧密合作,研究成果多次被体Südwest Presse德国知名媒报道,受邀在SICC, IUPAC Macro, China Nano,中国化学会学术年会等国际国内学术会议上做邀请报告,并担任Materials等期刊的客座编辑和ACS Nano, Small, Nanoscale等期刊的审稿人,获得了乌尔姆大学优秀博士论文奖,Forschungsbonus,Reaxys PhD Prize提名奖等荣誉。

 

研究方向

1)人工酶合成生物学

2) DNA折纸术

3) 复合生物高分子材料

4) 纳米医药及靶向药物载体

5) 智能生物纳米材料


发表论文

 1.       Yuzhou Wu*, Longjie Li, Larissa Frank, Jessica Wagner, Patrizia Andreozzi, Brenton Hammer, Marco D’Alicarnasso, Maria Pelliccia, Weina Liu, Sabyasachi Chakrabortty, Silke Krol, Johanna,  Simon, Katharina Landfester, Seah Ling Kuan, Francesco Stellacci, Klaus Müllen, Florian Kreppel*, Tanja Weil*, ACS Nano, 2019, doi: 10.1021/acsnano.9b01484

2.       Xuemei Xu, Shiqi Fang, Yuan Zhuang, Shanshan Wu, Qingling Pan, Longjie Li, Xiaohui Wang, Xueqing Sun, Bifeng Liu, Yuzhou Wu*, Cationic Albumin Encapsulated DNA Origami for Enhanced Cellular Transfection and Stability, Materials, 2019, 12, 949.

3.       Yan Li, Longjie Li, Xunbo Lu, Yulong Bai, Yufan Wang, Yuzhou Wu* and Fangrui Zhong* "Bioinspired radical cyclization of tryptamines: synthesis of peroxypyrroloindolenines as potential anti-cancer agents" Chem. Commun., 2019, 55, 63.

4.       Qile Yu, Yu Fu, Jianjian Huang, Jingyang Qin, Honghua Zuo, Yuzhou Wu*, Fangrui Zhong*, "Enantioselective Oxidative Phenol-Indole [3+ 2] Coupling Enabled by Biomimetic Mn (III)/Brønsted Acid Relay Catalysis" ACS Catal. 2019, 9, 7285

5.       Tanghui Duan, Liu He, Yu Tokura, Xin Liu, Yuzhou Wu*, Zhengshuang Shi*. Construction of tunable peptide nucleic acid junctions. Chem. Commun., 2018, 54, 2846.

6.       Yu Tokura#, Sean Harvey#, Chaojian Chen, Yuzhou Wu*, David Y. W. Ng*, Tanja Weil*. Fabrication of Defined Polydopamine Nanostructures by DNA Origami-Templated Polymerization. Angew. Chem. Int. Ed. 2018, 57, 1587 –1591.

7.       Yu Tokura, Sean Harvey, Yuzhou Wu, * David Y. W. Ng *,Tanja Weil *.Polymer tube nanoreactors via DNA-origami templated synthesis. Chem. Commun., 2018, 54, 2808.

8.       Weina Liu, Felix Boldt, Yu Tokura, Tao Wang, Bikram Keshari Agrawalla, Yuzhou Wu* and Tanja Weil*, Encoding function into polypeptide-oligonucleotide precision biopolymers, Chem. Commun., 2018, 54, 11797-11800.

9.       Sylvia Schmid,* Jasmina Gačanin, Yuzhou Wu, Tanja Weilbd, Peter Bäuerlea. Synthesis and bioconjugation of first alkynylated poly(dithieno[3,2-b:2′,3′-d]pyrrole)s. Polym. Chem., 2017,8, 7113-7118.

10.       David Y. W. Ng*, Roman Vill, Yuzhou Wu, Kaloian Koynov, Yu Tokura, Weina Liu, Susanne Sihler, Andreas Kreyes, Sandra Ritz, Holger Barth, Ulrich Ziener*, Tanja Weil*. Directing intracellular supramolecular assembly with N-heteroaromatic quaterthiophene analogues. Nature Communications, 2017, 8: 1850.

11.     Jasmina Gačanin, Anna Kovtun, Stephan Fischer, Victoria Schwager, Johanna Quambusch, Seah Ling Kuan, Weina Liu, Felix Boldt, Chuang Li, Zhongqiang Yang, Dongsheng Liu, Yuzhou Wu*, Holger Barth*, Anita Ignatius*. Spatiotemporally Controlled Release of Rho-Inhibiting C3 Toxin from a Protein–DNA Hybrid Hydrogel for Targeted Inhibition of Osteoclast Formation and Activity. Adv. Healthcare Mater. 2017, 6, 17.

12.     Brenton A. G. Hammer, Yuzhou Wu, Stephan Fischer, Weina Liu, Tanja Weil*, Klaus Müllen*. Controlling Cellular Uptake and Toxicity of Polyphenylene Dendrimers by Chemical Functionalization. Chembiochem, 2017, 18(10), 960-964.

13.     Zhi Zuo, Tatiana Syrovets, Yuzhou Wu, Susanne Hafner, Ina Vernikouskaya, Weina Liu, Genshan Ma, Tanja Weil, Thomas Simmet, Volker Rasche*. The CAM cancer xenograft as a model for initial evaluation of MR labelled compounds. Scientific Reports, 2017,7:4669

14.     Sabyasachi Chakrabortty, Miguel Sison, Yuzhou Wu, Anita Ladenburger, Goutam Pramanik, Johannes Biskupek, Jerome Extermann, Ute Kaiser, Theo Lasser, Tanja Weil*. NIR-emitting and photo-thermal active nanogold as mitochondria-specific probes. Biomater. Sci., 2017, 5, 966-971.

15.     Yuzhou Wu, Tanja Weil, Nanodiamonds for Biological Applications, Physical Sciences Reviews, 2017, DOI: 10.1515/9783110284645-009.

16.     Beatriz Pelaz, Christoph Alexiou, Ramón A Alvarez-Puebla, … Yuzhou Wu, …Wolfgang J. Parak*, Diverse Applications of Nanomedicine, ACS Nano, 2017, 11(3), 2313-2381.

17.     Yuzhou Wu*, Fedor Jelezko, Martin Plenio, Tanja Weil*, Diamond Quantum Devices in Biology, Angew. Chem. Int. Ed., 2016, 55, 6586-6598.

18.     Yu Tokura#, Yanyan Jiang#, Alexander Welle, Martina H Stenzel, Katarzyna Krzemien, Jens Michaelis, Christopher Barner-Kowollik, Yuzhou Wu*, Tanja Weil*, Bottom-up Fabrication of Nanopatterned Polymers on DNA Origami Nanotile by In-situ Atom Transfer Radical polymerization. Angew. Chem. Int. Ed. 2016,55, 5692-5697.

19.     Weina Liu, Boris Naydenov, Sabyasachi Chakrabortty, Bettina Wuensch, Kristina Hübner, Sandra Ritz, Helmut Cölfen, Holger Barth, Kaloian Koynov, Haoyuan Qi, Robert Leiter, Rolf Reuter, Jörg Wrachtrup, Felix Boldt, Jonas Scheuer, Ute Kaiser, Miguel Sison, Theo Lasser, Philip Tinnefeld, Fedor Jelezko, Paul Walther, Yuzhou Wu*, and Tanja Weil*. Fluorescent Nanodiamond–Gold Hybrid Particles for Multimodal Optical and Electron Microscopy Cellular Imaging. Nano Lett., 2016, 16 (10), 6236–6244.

20.     Sylvia Schmid*, David. Y. W. Ng, Elena. Mena-Osteritz, Yuzhou Wu, Tanja Weil, Peter Bäuerle, Self-assembling oligothiophene–bolaamphiphiles for loading and controlled release of doxorubicin into living cells. Chem. Commun., 2016, 52, 3235-3238.

21.     Christiane Seidler, David. Y. W. Ng, Yuzhou Wu and Tanja Weil*. pH responsive supramolecular core-shell protein hybrids, Supramolecular Chemistry, 2016, 28(9-10), 742-746.

22.     Seah Ling Kuan, Christina Förtsch, David Y. W. Ng, Stephan Fischer, Yu Tokura, Weina Liu, Yuzhou Wu, Kaloian Koynov, Holger Barth, Tanja Weil*, A supramolecular approach toward bioinspired PAMAM-dendronized fusion toxins, Macromol. Biosci. 2016, 16, 803−810.

23.     Tao Wang#, Andreas Riegger#, Markus Lamla, Sebastian Wiese, Patrick Oeckl, Markus Otto, Yuzhou Wu, Stephan Fischer, Holger Barth, Seah Ling Kuan, Tanja Weil*, Water-soluble allyl sulfones for dual site-specific labelling of proteins and cyclic peptides, Chem. Sci., 2016, 7, 3234-3239.

24.     Felix Boldt, Weina Liu, Yuzhou Wu*, Tanja Weil*. Converting Human Proteins into Precision Polymer Therapeutics. Curr Pharm Des., 2016, 22, 2866-2872.

25.     David Palesch, Felix Boldt, Janis A. Müller, Klaus Eisele, Christina M. Stürzel, Yuzhou Wu*, Jan Münch*, Tanja Weil*. PEGylated cationic serum albumin to boost retroviral gene transfer. ChemBioChem, 2016, 17(16), 1504-1508.

26.     Tao Wang, Yuzhou Wu, Seah Ling Kuan, Oliver Dumele, Markus Lamla, David Y. W. Ng, Matthias Arzt, Jessica Thomas, Jan. O. Mueller, Christopher Barner-Kowollik*, Tanja Weil*, A Disulfide Intercalator Toolbox for Site-Directed Polypeptide Modification, Chemistry – a European Journal, 2015, 21, 228-238.

27.     Tao Wang, Yuzhou Wu, MarkusLamla, David Y. W.Ng,* Sven Rau* and TanjaWeil*, Receptor Selective Ruthenium-Somatostatin Photosensitizer for Cancer Targeted Photodynamic Applications, Chem. Commun. 2015, 51, 12552-12555.

28.     Tao Zhang, Yuzhou Wu, Alexander Högele*, Tanja Weil* and Tim Liedl*, DNA-based self-assembly of fluorescent nanodiamonds, J. Am. Chem. Soc., 2015, 31, 9776–9779.

29.     Yuzhou Wu*, Fedor Jelezko*, Tanja Weil*, Programmable Biopolymers for Advancing Biomedical Applications of Fluorescent Nanodiamonds. Adv. Funct. Mater. 2015, 25, 6576–6585.

30.     Yuzhou Wu, David Yuen Wah Ng, Seah Ling Kuan, Tanja Weil*, “Protein-Polymer Therapeutics – A Macromolecular Perspective”, Biomaterials Science, 2015, 3, 214-230.

31.     René Stangenberg#, Yuzhou Wu#, Seah Ling Kuan, Dennis Kurzbach, Dariush Hinderberger, Jana Hedrich, Malin Insa Preiß, Heiko J. Luhmann, Tanja Weil* and Klaus Müllen*, A Polyphenylene Dendrimer Drug Transporter with Precisely Positioned Amphiphilic Surface Patches. Adv. Healthcare Mater. 2015, 4, 377–384.

32.     Yuzhou Wu*, Chuang Li, Felix Boldt, Christina Förtsch, Holger Barth, Yanran Wang, Seah Ling Kuan, Thuy Tam Tran, Viktoria Mikhalevich, Zhongqiang Yang, Dongsheng Liu*, Tanja Weil*. Programmable protein–DNA hybrid hydrogels for the immobilization and release of functional proteins. Chem. Commun., 2014,50, 14620-14622.

33.     David Yuen Wah Ng#, Yuzhou Wu#, Seah Ling Kuan and Tanja Weil*. Programming Supramolecular Biohybrids as Precision Therapeutics. Acc. Chem. Res., 2014, 47, 3471-3480. (#Shared first authorship).

34.     Chuang Li, Ping Chen, Yu Shao, Xu Zhou, Yuzhou Wu, Zhongqiang Yang, Zhibo Li, Tanja Weil, Dongsheng Liu*, A writable polypeptide-DNA hydrogel with rationally designed multi-modification sites, Small, 2014, 11, 1138-1143.

35.     Tao Wang, David Y. W. Ng, Yuzhou Wu, Jessica Thomas, Thuy TamTran and Tanja Weil*. Bis-sulfide bioconjugates for glutathione triggered tumor responsive drug release. Chem. Commun., 2014, 50, 1116-1118.

36.     David Y. W. Ng, Matthias Arzt, Yuzhou Wu, Seah Ling Kuan, Markus Lamla, Tanja Weil*. Constructing Hybrid Protein Zymogens through Protective Dendritic Assembly. Angew. Chem. Int. Ed. 2014, 53, 324-328.

37.     Christoph Meier, Yuzhou Wu, Goutam Pramanik, Tanja Weil*. Self-Assembly of High Molecular Weight Polypeptide Copolymers Studied via Diffusion Limited Aggregation. Biomacromolecules, 2014, 15, 219-227.

38.     David Y. W. Ng, Jörg Fahrer, Yuzhou Wu, Klaus Eisele, Seah Ling Kuan, Holger Barth*, Tanja Weil*. Efficient Delivery of p53 and Cytochrome C by Supramolecular Assembly of a Dendritic Multi-Domain Delivery System. Adv. Healthcare Mater., 2014, 2, 1620-1629.

39.     Yuzhou Wu, Susann Ihme, Michaela Feuring-Buske, Seah Ling Kuan, Klaus Eisele, Markus Lamla, Yanran Wang, Christian Buske, Tanja Weil*. A Core-shell Albumin Copolymer Nanotransporter for High Capacity Loading and Two-step Release of Doxorubicin with Enhanced Anti‐Leukemia Activity. Adv. Healthcare Mater. 2013, 2, 884–894.

40.     Diego Pesce#, Yuzhou Wu#, Anke Kolbe, Tanja Weil* and Andreas Herrmann*. Enhancing Cellular Uptake of GFP via Unfolded Supercharged Protein Tags. Biomaterials, 2013, 34, 4360. (#Shared first authorship)

41.     Seah Ling Kuan, David Y. W. Ng, Yuzhou Wu, Christina Förtsch, Holger Barth, Mikheil Doroshenko, Kaloian Koynov, Christoph Meier, Tanja Weil*.pH Responsive Janus-like Supramolecular Fusion Proteins for Functional Protein Delivery. J. Am. Chem. Soc. 2013, 135 (46), 17254–17257.

42.     Jana Hedrich, Yuzhou Wu, Manfred Schmidt. Polymer Complexes in Biological Applications. Adv. Polym. Sci. 2013, doi: 10.1007/12_2013_229. (Book Chapter).

43.     Tao Wang, Yuzhou Wu, Tanja Weil*. A Versatile and Orthogonal Approach for the Cross-Conjugation of DNA, Proteins and Peptides via the pH Switch. Chem. Sci., 2013, 4, 1889-1894.

44.     Seah Ling Kuan, Yuzhou Wu, Tanja Weil*. Precision Biopolymers from Protein Precursors for Biomedical Applications. Macromol Rapid Commun., 2013, 34, 380.

45.     Seah Ling Kuan, Bettina Stöckle, David Y.W. Ng, Yuzhou Wu, Mikheil Doroshenko, Jörg Reichenwallner, Kaloian Koynov, Dariush Hinderberger, Klaus Müllen, Tanja Weil*. Dendronized Albumin Biohybrids as Efficient Core-Shell Doxorubicin Delivery Systems, Biomacromolecules, 2013, 14 (2): 367–376.

46.     Yuzhou Wu, Klaus Eisele, Mikheil Doroshenko, Gerardo Algara-Siller, Ute Kaiser, Kaloian Koynov, Tanja Weil*. A Quantum Dot Photoswitch for DNA Detection, Gene Transfection, and Live-Cell Imaging. Small, 2012, 8(22): 3465–3475. (Cover article)

47.     Yuzhou Wu, Goutam Pramanik, Klaus Eisele, Tanja Weil*. Convenient Approach to Polypeptide Copolymers Derived from Native Proteins. Biomacromolecules, 2012, 13(6):1890-1898.

48.     Yuzhou Wu, Tao Wang, David Y.W. Ng, Tanja Weil*. Multifunctional Polypeptide-PEO Nanoreactors via the Hydrophobic Switch. Macromol. Rapid Commun., 2012, 33(17):1474-1481.

49.     Yuzhou Wu, Tanja Weil*. An Efficient Approach for Preparing Giant Polypeptide Triblock Copolymers by Protein Dimerization. Macromol. Rapid Commun., 2012, 33(15):1304-1309.

50.     Yuzhou Wu, Kai Shih Er, Arvind Ramanathan, Subhash Vasudevan, Tanja Weil*. Nano-sized Albumin-copolymer Micelles for Efficient Doxorubicin Delivery. Biointerphases. 2012, 7(1-4):5.

51.     Yasar Akdogan, Yuzhou Wu, Klaus Eisele, Manuela Schaz, Tanja Weil* and Dariush Hinderberger*. Host-Guest Interactions in Polycationic Human Serum Albumin Bioconjugates. Soft Matter, 2012, 8(43): 11106-11114.

52.     Tanja Weil, Goutam Pramanik, Yuzhou Wu. Protein-based copolymers for bioimaging and drug delivery applications. Polymer Preprints (American Chemical Society, Division of Polymer Chemistry), 2011, 52(1): no page given.

53.     Yuzhou Wu, Sabyasachi Chakrabortty, Radu A. Gropeanu, Joerg Wilhelmi, Yang Xu, Kai Shih Er, Seah Ling Kuan, Kaloian Koynov, Yinthai Chan* and Tanja Weil*. pH-Responsive Quantum Dots via an Albumin Polymer Surface Coating, J. Am. Chem. Soc., 2010, 51(1): 786-787.

54.     Yuzhou Wu, Tanja Weil. Multifunctional protein- hybrid and its applications in quantum dot coatings. Polymer Preprints (American Chemical Society, Division of Polymer Chemistry), 2010, 51(1): 786-787.


  • 教育经历Education Background
  • 工作经历Work Experience
  • 研究方向Research Focus
  • 社会兼职Social Affiliations
  • 人工酶合成生物学
  • DNA折纸术
  • 复合生物高分子材料
  • 纳米医药及靶向药物载体
  • 智能生物纳米材料