华中科技大学主页平台管理系统向明--中文主页--科学研究

研究领域

抗炎免疫药理学，主要包括：研究基于天然免疫与获得性免疫相关联的自身免疫性疾病（T1D，RA，AIH等）及慢性炎症（胰腺炎、糖尿病肾病和胰岛素抵抗）发病机制；研究基于表观遗传和细胞代谢的免疫细胞功能转化机制；研究抗肿瘤免疫治疗的方式及机制；研究化学及中药新型免疫抑制剂的作用及机制。

论文成果

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Xiang M, Zaccone P, Di Marco R, Magro G, Di Mauro M, Beltrami B, Meroni PL, Nicoletti F. Prevention by rolipram of concanavalin A-induced T-cell-dependent hepatitis in mice. Eur J Pharmacol. 1999; 367(2-3): 399-404..
Xiang M, Zaccone P, Di Marco R, Harris R, Magro G, Di Mauro M, Meroni PL, Garotta G, Nicoletti F. Failure of exogenously administered interferon-gamma or blockage of endogenous interleukin-4 with specific inhibitors to augment the incidence of autoimmune diabetes in male NOD mice. Autoimmunity. 1999; 30(2):71-80..
Di Marco R,Xiang M, Zaccone P, Leonardi C, Franco S, Meroni P, Nicoletti F. Concanavalin A-induced hepatitis in mice is prevented by interleukin (IL)-10 and exacerbated by endogenous IL-10 deficiency. Autoimmunity. 1999; 31(2): 75-83..
Nicoletti F, Di Marco R, Zaccone P,Xiang M, Magro G, Grasso S, Morrone S, Santoni A, Shoenfeld Y, Garotta G, Meroni P. Dichotomic effects of IFN-gamma on the development of systemic lupus erythematosus-like syndrome in MRL-lpr / lpr mice. Eur J Immunol. 2000; 30(2): 438-47..
Nicoletti F, Zaccone P,Xiang M, Magro G, Di Mauro M, Di Marco R, Garotta G, Meroni P. Essential pathogenetic role for interferon (IFN-)gamma in concanavalin -induced T cell-dependent hepatitis: exacerbation by exogenous IFN-gamma and prevention by IFN-gamma receptor-immunoglobulin fusion protein. Cytokine. 2000; 12(4): 315-23..
Xiang M, Eisenbach C, Ernst E, Weigand K, Stremmel W, Encke J. Humoral and cellular immune responses elicited by immunization with genetically modified dendritic cells expressing HCVNS3. Hepatology. 2005; 42 (4) Suppl.1:248A.

专利

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科研项目

科学研究

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