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导师介绍

钟芳锐，华中科技大学化学与化工学院教授，博士生导师。2008年本科毕业于浙江大学化学系，2012年获得新加坡国立大学博士学位，师从新加坡国家科学院院士卢一新教授，2013年至2015年先后在德国慕尼黑工业大学和乌尔姆大学从事博士后研究，德国洪堡学者，师从德国科学院院士Thorsten Bach教授，2015年12月起任华中科技大学教授。

钟芳锐教授主要从事绿色有机合成化学领域的研究，主要方向包括人工酶催化有机合成、小分子仿生催化与仿生反应、绿色有机合成等。研究成果在Nature、J. Am. Chem. Soc.，Angew. Chem. Int. Ed., ACS Catal.等期刊发表论文50余篇，中国发明专利授权6项。获得新加坡国家化学研究所金质奖章、Thieme Chemistry Journal Award、德国洪堡奖学金、国家优秀留学生奖等荣誉。

研究方向

1、人工酶催化有机合成

2、小分子仿生催化与仿生反应

3、绿色有机合成

代表性论文  

56. Jianjian Huang, Tai-Ping Zhou, Ningning Sun, Huaibin Yu, Xixiang Yu, Rong-Zhen Liao*, Weijun Yao, Zhifeng Dai, Guojiao Wu & Fangrui Zhong*,  Accessing ladder-shape azetidine-fused indoline pentacycles through intermolecular regiodivergent aza-Paternò–Büchi reactions, Nat Commun. 2024, 15, 1431.

55. Xutong Ye (本科生), Xixiang Yu (本科生), Rui Deng (本科生), Fangrui Zhong*, Guojiao Wu*, Catalytic Synthesis of Atropoisomers via Non-Canonical Friedel-Crafts Reactions,  Adv. Synth. Catal.  2024, https://doi.org/10.1002/adsc.202400084

54. Yu Fu, Yan Xia, Yingru Xu, Xutong Ye, Shangxian Xie, Yuzhou Wu, Weining Zhao*, Fangrui Zhong*, A Recyclable Supramolecular Photocatalyst for the Chemoselective [2 + 2] Photocycloaddition of Chalcones in Water, ACS Sustainable Chem. Eng. 2023, 11, 17752.

53. Yu Fu, Xiaohong Liu, Yan Xia, Xuzhen Guo, Juan Guo, Junshuai Zhang, Weining Zhao, Yuzhou Wu, Jiangyun Wang, Fangrui Zhong, Whole-cell-catalyzed hydrogenation/deuteration of aryl halides with a genetically repurposed photodehalogenase. Chem, 2023, 9, 1897.

52. Huan Guo, Ningning Sun, Juan Guo, Tai-Ping Zhou, Langyu Tang, Wentao Zhang, Yaming Deng, Rong-Zhen Liao, Yuzhou Wu, Guojiao Wu, Fangrui Zhong*. Expanding the Promiscuity of a Copper‐Dependent Oxidase for Enantioselective Cross‐Coupling of Indoles. Angew. Chem. Int. Ed. 2023, e202219034.

51. Ningning Sun, Jianjian Huang, Junyi Qian, Taiping Zhou, Juan Guo, Langyu Tang, Wentao Zhang, Yaming Deng, Weining Zhao, Guojiao Wu, Rongzhen Liao, Xi Chen*, Fangrui Zhong* & Yuzhou Wu*, Enantioselective [2+2]-cycloadditions with triplet photoenzymes. Nature 2022, 611, 715.

50. Muhammad Adnan Bashir, Jian Wei, Huifei Wang, Fangrui Zhong*, Hongbin Zhai*, Org. Chem. Front. 2022, 9, 5395.

49. Huan Guo, Jin Liu, Guojiao Wu, Weijun Yao, Fangrui Zhong*, Synthesis of isochromanones via laccase-mediated oxidative [4+2] cyclization of pyrocatechuic acid with styrenes, Green Chem. 2022,  24, 5598-5603.

48.Jingyang Qin,Tong Zhou,Taiping Zhou,Langyu Tang,Honghua Zuo,Huaibin Yu,Guojiao Wu,Yuzhou Wu,Rong-Zhen Liao*,Fangrui Zhong*,Catalytic Atroposelective Electrophilic Amination of Indoles, Angew. Chem. Int. Ed. 2022, e202205159.

47. Muhammad Adnan Bashir, Langyu Tang, Longjie Li, Huaibin Yu, Weijun Yao, Guojiao Wu* and Fangrui Zhong*, Org. Chem. Front., 2022, 10.1039/D1QO01942B.

46. Yaming Deng, Quan Zhou, Yuzhou Wu, Xi Chen* and Fangrui Zhong*, Properties and Mechanisms of Flavin-Dependent Monooxygenases and Their Applications in Natural Product Synthesis, Int. J. Mol. Sci. 2022, 23, 2622.

45. 左鸿华，钟芳锐，亚稳醌类分子的活性调控与仿生催化反应，有机化学，2022，DOI：10.6023/cjoc202108032 （邀请研究专题综述）.

44. Muhammad Adnan Bashir‡, Yulong Zhang‡, Huaibin Yu, Bofei Wang,Weining Zhao and Fangrui Zhong*, Bimetallic copper/cobalt-cocatalyzed double aerobic phenol oxidation/cyclization toward π-extended benzofuro[2,3-b]indoles as electron donors for electroluminescence, Green Chem., 2021, 23, 5031-5036.

43. Yu Fu,# Jian Huang,# Yuzhou Wu,* Xiaohong Liu,* Fangrui Zhong,* and Jiangyun Wang*, “Biocatalytic Cross-Coupling of Aryl Halides with a Genetically Engineered Photosensitizer Artificial Dehalogenase” J. Am. Chem. Soc. 2021, 143, 617.

42. Yang Ni, Xiang Wan, Honghua Zuo, Muhammad Adnan Bashir, Yu Liu, Huaibin Yu, Rong-Zhen Liao, Guojiao Wu,* and Fangrui Zhong,* “Iron-catalyzed Cross-Dehydrogenative C-H Amidation of Benzofurans and Benzothiophenes with Anilines” Org. Chem. Front., 2021, 8， 1490. 

41. Tai-Ping Zhou, Fangrui Zhong,* Yuzhou Wu and Rong-Zhen Liao,* “Regioselectivity and stereoselectivity of intramolecular [2 + 2] photocycloaddition catalyzed by chiral thioxanthone: a quantum chemical study”, Org. Biomol. Chem. 2021, 19, 1532.

40. Xunbo Lu, Yulong Bai, Jingyang Qin, Nan Wang, Yuzhou Wu,* and Fangrui Zhong*, “Alleviating Catalyst Decay Enables Efficient Intermolecular C(sp3)−H Amination under Mechanochemical Conditions” ACS Sustainable Chem. Eng, 2021, 9, 1684-1691.

39. Jingyang Qin, Honghua Zuo, Yang Ni, Qile Yu, and Fangrui Zhong*, “Catalytic Electrophilic C−H Sulfenylation of Indoles with Disulfides under Ball Milling”, ACS Sustainable Chem. Eng. 2020, 8, 12342−12347.

38. Honghua Zuo, Jingyang Qin, Wentao Zhang, Muhammad Adnan Bashir, Qile Yu, Weining Zhao, Guojiao Wu,* and Fangrui Zhong*, “Hemin-Catalyzed Oxidative Phenol-Hydrazone [3+3] Cycloaddition Enables Rapid Construction of 1,3,4-Oxadiazines” Org. Lett. 2020, 22, 6911−6916.

37. Adnan Bashir, Honghua Zuo, Xunbo Lu, Yuzhou Wu, Fangrui Zhong, Chem. Commun., 2020, 56, 5965.

36. Dangrui Wang, Huaibin Yu, Shaohan Sun, Fangrui Zhong*, "Intermolecular Vicinal Diaminative Assembly of Tetrahydroquinoxalines via Metal-free Oxidative [4 + 2] Cycloaddition Strategy" Org. Lett. 2020, 6. 2425.

35. Juan Guo, Huan Guo, Jin Liu,* Fangrui Zhong, Yuzhou Wu*,"Manganese(II) Oxidizing Bacteria as Whole-Cell Catalyst for β-Keto Ester Oxidation" Int. J. Mol. Sci. 2020, 21, 1709.

34. Yan Li,Juan Guo, Xunbo Lu and Fangrui Zhong*, "One-step assembly of alkoxypyrroloindolines via iodine-catalyzed alkoxycyclization of indole derivatives" Org. Biomol. Chem., 2020, 18, 32-35.

33. Yu Fu,Qile Yu,Yulong Zhang,Zhonghong Gao,* Yuzhou Wu * and Fangrui Zhong*,"Hemin-catalyzed biomimetic oxidative phenol–indole [3 + 2] reactions in aqueous media",Org. Biomol. Chem., 2019, 17, 9994-9998. Part of the themed collection: Chemical biology in OBC.

32. Dangui Wang, Xunbo Lu, Shaohan Sun, Huaibin Yu, Huimin Su, Yuzhou Wu,* Fangrui Zhong* "Unified and Benign Synthesis of Spirooxindoles via Bifunctional and Recyclable Iodide Salt‐Catalyzed Oxidative Coupling in Water" Eur. J. Org. Chem. 2019, 35, 6028.

31. Qile Yu, Yu Fu, Jianjian Huang, Jingyang Qin, Honghua Zuo, Yuzhou Wu*, Fangrui Zhong*, "Enantioselective Oxidative Phenol-Indole [3+ 2] Coupling Enabled by Biomimetic Mn (III)/Brønsted Acid Relay Catalysis" ACS Catal. 2019, 9, 7285.

30. Chun Ding, Xuan Zhang, Liang Shen, Jiaqi Huang, Ang Lu, Fangrui Zhong*, Yan Wang*, "Application of polysaccharide derivatives as novel draw solutes in forward osmosis for desalination and protein concentration", Chem Eng Res Des, 2019, 146, 211.

29. Yufeng Shi, Yufan Wang, Xunbo Lu, Yulong Zhang, Yuzhou Wu, Fangrui Zhong*, "Rhodium-catalyzed aminohydroxylation of unactivated alkenes in aqueous media for the benign synthesis of 1, 2-amino alcohols" Green Chem, 2019, 21, 780.

28. Yan Li, Longjie Li, Xunbo Lu, Yulong Bai, Yufan Wang, Yuzhou Wu* and Fangrui Zhong* "Bioinspired radical cyclization of tryptamines: synthesis of peroxypyrroloindolenines as potential anti-cancer agents" Chem. Commun., 2019, 55, 63.

27. Xunbo Lu, Yulong Bai, Yan Li, Yufeng Shi, Longjie Li, Yuzhou Wu and Fangrui Zhong* "Assembly of C3a-Peroxylated Pyrroloindolines via Interrupted Witkop Oxidation" Org. Lett., 2018, 20, 7937.

26. Yang Ni, Honghua Zuo, Huaibin Yu, Yuzhou Wu, and Fangrui Zhong* "Synergistic Catalysis-Enabled Thia-Aza-Prins Cyclization with DMSO and Disulfides: Entry to Sulfenylated 1,3-Oxazinanes and Oxazolidines" Org. Lett. 2018, 20, 5899.

25. Yang Ni, Honghua Zuo, Yan Li, Yuzhou Wu, and Fangrui Zhong*  "Copper-Catalyzed Regioselective Intramolecular Electrophilic Sulfenoamination via Lewis Acid Activation of Disulfides under Aerobic Conditions"  Org. Lett. 2018, 20, 4350.

24.Yushuang Yu, Yu Fu, Fangrui Zhong*, "Benign catalysis with iron: facile assembly of cyclobutanes and cyclohexenes via intermolecular radical cation cycloadditions" Green Chem. 2018, 21, 1743.

23. Yang Ni, Qile Yu, Qihao Liu, Honghua Zuo, Huai-Bin Yu, Wen-Jie Wei, Rong-Zhen Liao, and Fangrui Zhong*, "Iron-Catalyzed Regiospecific Intermolecular Radical Cyclization of Anilines: Strategy for Assembly of 2,2-Disubstituted Indolines" Org. Lett., 2018, 20, 1404.

22. Xunbo Lu,Yufeng Shi and Fangrui Zhong* "Rhodium-catalyzed intermolecular C(sp3)–Hamination in a purely aqueous system" Green Chem. 2018, 20, 113.(This article is part of the themed collection: 2018 Green Chemistry Hot Articles)

21. Tianli Wang, Xiaoyu Han, Fangrui Zhong, Weijun Yao, Yixin Lu. “Amino acid-derived Bifunctional Phosphines for Enantioselective Transformations” Acc. Chem. Res.,2016, 49, 1369.

20. Fangrui Zhong, Alexander Pöthig, Thorsten Bach. “Synergistic Stereocontrol in the Enantioselective Ruthenium- catalyzed Sulfoxidation of Spirodithiolane-Indolones” Chem. Eur. J. 2015, 21, 10310.

19. Tianli Wang, Weijun Yao, Fangrui Zhong, Guohao Pang, Yixin Lu. “Phosphine-Catalyzed Enantioselective g-Addition of 3-Substituted Oxindoles to 2,3-Butadienoates and 2-Butynoates: Use of Prochiral Nucleophiles”, Angew. Chem. Int. Ed. 2014, 53, 2964.

18. Fangrui Zhong, Thorsten Bach. “Enantioselective Construction of 2,3-Dihydrofuro[2,3-b]quinolines through Supramolecular Hydrogen Bonding Interactions” Chem. Eur. J. 2014, 20, 13522.

17. Fangrui Zhong,Xiaowei Dou, Weijun Yao, Qiang Zhu, Yixin Lu.“Chiral Phosphine-Catalyzed Asymmetric Michael Addition of Oxindoles” Angew. Chem. Int.Ed. 2013, 52, 943.(highlighted in SYNFACTS2013, 216)

16. Jie Luo, Haifei Wang, Fangrui Zhong, Jacek, Kwiatkowski, Li-Wen Xu, Yixin Lu. “Highly diastereoselective and enantioselective direct Michael addition of phthalide derivatives to nitroolefins” Chem. Commun. 2013, 49, 5775.

15. Xiaowei Dou, Bo Zhou, Weijun Yao, Fangrui Zhong, Chunhui Jiang, Yixin Lu. “A Facile and Versatile Approach for the Asymmetric Synthesis of Oxindoles with a 3-Sulfenyl -substituted Quaternary Stereocenter”.Org. Lett. 2013, 15, 4920.

14. Fangrui Zhong,Jie Luo, Guo-Ying Chen, Xiaowei Dou, Yixin Lu. “Highly Enantioselective Regiodivergent Allylic Alkylations of MBH Adducts with Phthalides” J. Am. Chem. Soc. 2012, 134, 10222.(highlighted in SYNFACTS 2012, 906)

13. Fangrui Zhong, Xiaoyu Han, Youqing Wang, Yixin Lu. “Highly Enantioselective [4 + 2] Annulations Catalyzed by Amino Acid-Based Phosphines: Synthesis of Functionalized Cyclohexenes and 3-Spirocyclohexene-2-oxindoles”, Chem. Sci. 2012, 3, 1231.

12. Xiaoyu Han, Fangrui Zhong, Youqing Wang, Yixin Lu. “Versatile Enantioselective [3 + 2] Cyclization between Imines and Allenoates Catalyzed by Dipeptide-Based Phosphines”, Angew. Chem. Int. Ed. 2012, 51, 767.

11. Jie Luo, Haifei Wang, Fangrui Zhong, Jacek Kwiatkowski, Li-Wen Xu, Yixin Lu. “Direct Asymmetric Mannich Reaction of Phthalides: Facile Access to Chiral Substituted Isoquinolines and Isoquinolinones”,Chem. Commun. 2012, 48, 4707.

10. Xiaowei Dou,Fangrui Zhong,Yixin Lu. “A Highly Enantioslective Synthesis of Functionalized 2,3-Dihydrofurans via a Modified Feist−Bénary Reaction” Chem. Eur.J. 2012, 18, 13945.

9. Guo-Ying Chen, Fangrui Zhong, Yixin Lu. “Asymmetric Allylic Alkylation of Isatin-derived Morita-Baylis-Hillman Carbonates with Nitroalkanes”, Org. Lett. 2012, 14, 3955.

8. Fangrui Zhong,Weijun Yao, Xiaowei Dou, Yixin Lu. “Enantioselective Construction of 3-Hydroxy Oxindoles via Decarboxylative Addition of b-Ketoacids to Isatins” Org. Lett. 2012, 14, 4018.

7. Fangrui Zhong,Guoying Chen, Xiaoyu Han, Weijun Yao, Yixin Lu. “Asymmetric Construction of Functionalized Bicyclic imides via [3+2] Annulation of MBH Carbonates Catalyzed by Dipeptide-based Phosphines” Org. Lett. 2012, 14, 3764.

6. Fangrui Zhong, Xiaoyu Han, Youqing Wang, Yixin Lu. “Highly Enantioselective [3+2] Annulation of Morita-Baylis-Hillman Adducts Mediated by L-Threonine Derived Bifunctional Phosphines: Creation of 3-Spirocyclopentene-2-oxindoles with Two Consecutive Quaternary Centers”, Angew. Chem. Int. Ed. 2011, 50, 7837. (highlighted in SYNFACTS 2011, 1020)

5. Fangrui Zhong, Youqing Wang, Xiaoyu Han, Kuo-Wei Huang, Yixin Lu. “L-Threonine-Derived Bifunctional Phosphine-Sulfonamide Catalyst-Promoted Enantioselective Aza-Morita-Baylis-Hillman Reaction”,Org. Lett. 2011, 13, 1310. (highlighted in SYNFACTS 2011, 551)

4. Fangrui Zhong, Guo-Ying Chen, Yixin Lu. “Enantioselective Morita-Baylis-Hillman Reaction of Isatins with Acrylates: Facile Creation of 3-Hydroxy-2-Oxindoles”, Org. Lett. 2011, 13, 82.

3. Xiaoyu Han, Youqing Wang, Fangrui Zhong, Yixin Lu. “Enantioselective [3 + 2] Cycloaddition of Allenes to Acrylates Catalyzed by Dipeptide-derived Novel Phosphines: Facile Creation of Functionalized Cyclopentenes Containing Quaternary Stereogenic Centers”, J. Am. Chem. Soc. 2011, 133, 1726.

2. Guo-Ying Chen, Fangrui Zhong, Yixin Lu. “Highly Enantioselective and Regiospecific Substitution of Morita-Baylis-Hillman Carbonates with Nitroalkanes” Org. Lett. 2011, 13, 6070.

1. Xiao Han, Fangrui Zhong, Yixin Lu. “Highly Enantioselective Amination Reactions of Fluorinated Ketoesters Catalyzed by Novel Chiral Guanidines Derived from Cinchona Alkaloids”, Adv. Synth. Catal. 2010, 352, 2778.