Indexed by: Journal paper

Journal: Advanced Functional Materials

Included Journals: SCI

Key Words: affinity, biosensors, imaging, molecular screening, surface plasmon resonance

Date of Publication: 2024-04-11

Impact Factor: 20.0

Abstract: Considering the improved detection of biological analytes for affinity analysis is highly desirable, a metasurface plasmon resonance (Meta-SPR)-based imaging system, incorporating a localized SPR sensing platform with different microfluidic systems and employing simple bright-field imaging, is established in this study. This system enables low-level analyte concentration analysis, ranging from 100 pm to 100 nm, with the real-time removal of nonspecific binding signals within the same device field of view. Combined with microfluidic systems and microdroplet spotting, it is possible to automatically measure the kinetic curves of a sample at ten concentration gradients or detect the specific responses of multiple samples in a single experiment simultaneously. This system can inexpensively and conveniently achieve complex detection functions, demonstrating an innovative breakthrough in sensor detection.