Targeted Computed Tomography Visualization and Healing of Inflammatory Bowel Disease by Orally Delivered Bacterial-Flagella-Inspired Polydiiododiacetylene Nanofibers
Release time:2023-07-10
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Indexed by:Journal paper
Journal:ACS Nano
Included Journals:SCI
Volume:17
Issue:4
Page Number:3873–3888
Key Words:polydiiododiacetylene, inflammatory bowel disease, targeted computed tomography imaging, reactive oxygen species,
gut microbiota
DOI number:10.1021/acsnano.2c12154
Date of Publication:2023-02-15
Impact Factor:17.1
Abstract:Accurate diagnosis and timely therapeutic intervention of inflammatory bowel disease (IBD) is essential in
preventing the progression of the disease, although it still
represents an insurmountable challenge. Here we report the
design of bacterial-flagella-inspired polydiiododiacetylene
(PIDA) nanofibers and its performance in targeted computed
tomography (CT) imaging and on-demand therapeutic
intervention of IBD. With a morphology mimicking bacterial
flagella, PIDA nanofibers attach on the mucus layer of the
gastrointestinal (GI) tract after oral administration, evenly
distributing on the GI surface to portray the GI lining under CT
scan within 2 h. PIDA can retain for a longer time in the damaged mucosa at the inflamed lesions than in normal GI tissues to
enable the targeted CT visualization of IBD. PIDA also scavenges reactive oxygen species and ameliorates gut dysbiosis
attributed to its iodine-substituted polydiacetylene structure, so that the enriched PIDA nanofibers at the targeted IBD lesions
can alleviate the inflammation while maintaining the gut microbiota homeostasis, thus promoting the rebalance of GI
microenvironment and the mucosal healing.
Links to published journals:https://doi.org/10.1021/acsnano.2c12154