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论文类型：期刊论文

通讯作者：罗亮

发表刊物：Advanced Materials

收录刊物：SCI

卷号：32

期号：43

页面范围：2004685

ISSN号：0935-9648

DOI码：10.1002/adma.202004685

发表时间：2020-09-22

影响因子：27.398

摘要：Near‐infrared (NIR) chemiluminescence (CL) emission is highly favorable for deep‐tissue imaging, but chemically conjugated NIR CL emitters with the aggregation‐induced emission (AIE) property for biotechnology are seldom reported. Herein, an AIE‐active NIR CL emitter, TBL, is synthesized by conjugating luminol unit with electron‐accepting benzothiadiazole and an electron‐donating triphenylamine, and subsequently TBL dots are prepared by using F127 as the surfactant. The CL emission of TBL dots can last continuously for over 60 min and can be employed for quantitative (in vitro) and qualitative (in vivo) detection of 1O2. Strikingly, the NIR CL emission can penetrate through tissues with a total thickness of over 3 cm, exhibiting significantly better performance than NIR fluorescence emission and blue CL emission. Moreover, the successful differentiation of tumor and normal tissues by TBL‐based CL imaging in vivo also paves the way for CL‐guided cancer diagnosis and surgery.

发布期刊链接：https://onlinelibrary.wiley.com/doi/10.1002/adma.202004685