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发表刊物：Chemical Research in Chinese Universities

收录刊物：SCI

卷号：37

期号：1

页面范围：137-142

ISSN号：1005-9040

关键字：Photodynamic therapy；Photosensitizer；Aggregation-induced emission；Mitochondria； Imaging-guided

DOI码：10.1007/s40242-021-0379-0

发表时间：2021-02-01

影响因子：1.063

摘要：Photosensitizers that can target and accumulate in mitochondria are expected to achieve good therapeutic effects in photodynamic therapy, as mitochondria are the energy generation factory in cells. Herein, we designed and synthesized a novel mitochondrion-targeting photosensitizer TPC-Py with aggregation-induced emission characteristics for image-guided photodynamic therapy. TPC-Py possessed an efficient production of 1O2, with a quantum yield of 11.65%, upon mild white light irradiation (6 mW/cm2). TPC-Py exhibited good biocompatibility under dark condition, but showed remarkable cytotoxicity towards human cervical carcinoma(HeLa) cells with a half maximal inhibitory concentration(IC50) of 3.2 µmol/L when exposed to white light irradiation(14.4 J/cm2). In addition, the Stokes shift of TPC-Py was as high as 150 nm, so that it could prevent self-absorption and increase the signal-to-noise ratio of fluorescence imaging. The excellent performance of TPC-Py makes it a promising candidate in imaging-guided clinical PDT for cancer in the near future.

发布期刊链接：https://link.springer.com/article/10.1007/s40242-021-0379-0