Indexed by: Unit Twenty Basic Research

Document Code: PMID: 26792065

First Author: Xiaoyang Wan

Correspondence Author: Weibin Zhou

Co-author: Mi-Sun Lee

Journal: American Journal of Physiology-Renal Physiology

Included Journals: SCI

Affiliation of Author(s): the University of Michigen

Place of Publication: USA

Discipline: Medicine

Volume: 310

Issue: (8)

Page Number: F777-F784

ISSN No.: 1522-1466

Date of Publication: 2016-04-15

Abstract: Activation of small GTPase Rac1 in podocytes is associated with rodent models of kidney injury and familial nephrotic syndrome. Induced Rac1 activation in podocytes in transgenic mice results in rapid transient proteinuria and foot process effacement, but not glomerular sclerosis. Thus it remains an open question whether abnormal activation of Rac1 in podocytes is sufficient to cause permanent podocyte damage. Using a number of transgenic zebrafish models, we showed that moderate elevation of Rac1 activity in podocytes did not impair the glomerular filtration barrier but aggravated metronidazo

Links to published journals: https://www.ncbi.nlm.nih.gov/pubmed/26792065