Indexed by: Unit Twenty Basic Research

Document Code: PMID: 29042681

First Author: Jing Wang

Correspondence Author: Hong Cao

Journal: Scientific Reports

Included Journals: SCI

Affiliation of Author(s): Institute of Hydrobiology, Chinese Academy of Sciences

Place of Publication: British

Discipline: Medicine

First-Level Discipline: Basic Medicine

Volume: 7

Issue: (1)

Page Number: 13419

ISSN No.: 0068-1261

Date of Publication: 2017-10-17

Abstract: Intrahepatic cholangiocarcinoma (ICC) is a highly malignant tumor, difficult to diagnose even at an early stage. In this study, we successfully constructed an nras61K-induced ICC model in zebrafish. Transcriptome analysis and gene set enrichment analysis (GSEA) of liver samples of the ICC and WT (wild-type) zebrafish revealed that the genes differentially expressed between the two groups were mainly involved in focal adhesion, chemokine signaling and metabolic pathways. Analysis of DNA methylomes revealed that compared with WT samples, methylated genes in ICC samples were enriched in functions

Links to published journals: https://www.ncbi.nlm.nih.gov/pubmed/29042681